Evidence map›Paper›PMID 35887646›Full record

ArticleJournal of personalized medicine2022

Personalized Medicine Approach in a DCM Patient with

Balram Neupane, Kabita Pradhan, Audrey Magdalena Ortega-Ramirez, Parwez Aidery, Vytautas Kucikas, Matthias Marks, Marc A M J van Zandvoort, Karin Klingel, Klaus K Witte, Stefan Gründer and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Balram NeupaneDepartment of Cardiology, Angiology and Critical Care (Medical Clinic 1), University Hospital RWTH Aachen, 52074 Aachen, Germany.
Kabita PradhanDepartment of Cardiology, Angiology and Critical Care (Medical Clinic 1), University Hospital RWTH Aachen, 52074 Aachen, Germany.
Audrey Magdalena Ortega-RamirezInstitute of Physiology, RWTH Aachen University, 52074 Aachen, Germany.
Parwez AideryDepartment of Cardiology and Angiology, University Hospital of Tübingen, 72076 Tübingen, Germany.
Vytautas KucikasInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Matthias MarksClinic for Neurology, Section Neurobiological Research, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-1820-1148
Marc A M J van ZandvoortInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Karin KlingelCardiopathology, Institute for Pathology, University Hospital of Tübingen, 72076 Tübingen, Germany.ORCID 0000-0003-0203-2498
Klaus K WitteDepartment of Cardiology, Angiology and Critical Care (Medical Clinic 1), University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-7146-7105
Stefan GründerInstitute of Physiology, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-7635-9883
Nikolaus MarxDepartment of Cardiology, Angiology and Critical Care (Medical Clinic 1), University Hospital RWTH Aachen, 52074 Aachen, Germany.
Michael GramlichDepartment of Cardiology, Angiology and Critical Care (Medical Clinic 1), University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0001-5233-6778
RWTH Aachen University · DEUniversity Children's Hospital Tübingen · DEMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMutations in the

methodsWe report a 47-year-old DCM patient with severely impaired left ventricular ejection fraction and NYHA functional class IV despite optimal heart failure treatment. Whole-exome sequencing revealed an LMNA E161K missense mutation as the pathogenetic cause for DCM in this patient. We generated a patient-specific

resultsBeta adrenergic stimulation of cardiomyocytes derived from

conclusionWe have successfully generated the first in vitro model to recapitulate a patient-specific LMNA E161K mutation which leads to a severe form of DCM. The model may serve as a template for individualized and specific treatment of heart failure.

Indexed as

familial DCMindividualized therapylamin mutationlaminopathymTOR inhibitor

Identifiers

PMID35887646
PMCPMC9323361
OpenAlexW4285733055

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.