Evidence map›Paper›PMID 35887687›Full record

ArticleJournal of personalized medicine2022

Potential Similarities in Sex Difference in Key Genes and Their Expression, Network, EQTL and Pathways between COVID-19 and Chronic Kidney Disease Based on Mouse Model.

Zhuo Yu, Jingyu Zhan, Wei Dong, Lu Lu, Monica M Jablonski, Lotfi Aleya, Jingyu Chen, Peiqing Zhang, Hong Chen, Weikuan Gu

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Zhuo YuHeilongjiang Academy of Traditional Chinese Medicine, Sanfu Road 142, Xiangfang District, Harbin 150040, China.
Jingyu ZhanDepartment of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150001, China.
Wei DongDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Monica M JablonskiDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Lotfi AleyaChrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, Université de Franche-Comté 16, Route de Gray, F-25030 Besançon, France.
Jingyu ChenDepartment of Chinese Medicine, First Clinical School of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Peiqing ZhangHeilongjiang Academy of Traditional Chinese Medicine, Sanfu Road 142, Xiangfang District, Harbin 150040, China.
Hong ChenHeilongjiang Academy of Traditional Chinese Medicine, Sanfu Road 142, Xiangfang District, Harbin 150040, China.
Weikuan GuDepartment of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150001, China.ORCID 0000-0003-1112-8088
University of Tennessee Health Science Center · USCentre National de la Recherche Scientifique · FRHarbin Medical University · CNHeilongjiang Academy of Sciences · CNHeilongjiang University of Chinese Medicine · CNMemphis VA Medical Center · US

Funding

University of Tennessee Health Science Center R073290109
6 · The paper itself

Abstract

COVID-19 and chronic kidney disease (CKD) share similarity in sex bias and key genes in the disease pathway of sex difference. We investigated the sex difference of molecular pathways of four key players of these two diseases using an existing large set of whole genome expression profiles from the kidneys of female and male mouse models. Our data show that there is little to no correlation at the whole genome expression level between female and male mice among these four genes. There are considerable sex differences among genes in upstream regulation,

Indexed as

chronic kidney diseaseCOVID-19eQTgenepathwaysex difference

Identifiers

PMID35887687
PMCPMC9323909
OpenAlexW4286499655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.