Evidence map›Paper›PMID 35889004›Full record

ReviewMicroorganisms2022

Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey.

Estefanía Calvo-Alvarez, Maria Dolci, Federica Perego, Lucia Signorini, Silvia Parapini, Sarah D'Alessandro, Luca Denti, Nicoletta Basilico, Donatella Taramelli, Pasquale Ferrante and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Estefanía Calvo-AlvarezDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-7509-7204
Maria DolciDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-1868-1444
Federica PeregoDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-1566-0231
Lucia SignoriniDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-6691-736X
Silvia ParapiniDepartment of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-2079-8892
Sarah D'AlessandroDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-9241-9762
Luca DentiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Nicoletta BasilicoDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-9030-1066
Donatella TaramelliDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-5108-4492
Pasquale FerranteDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Serena DelbueDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-3199-9369
University of Milan · IT

Funding

Ministry of Education, Universities and Research PRIN2017 Prot. 2017KM79NNUniversity of Milan PSR2020
6 · The paper itself

Abstract

More than two years have passed since the viral outbreak that led to the novel infectious respiratory disease COVID-19, caused by the SARS-CoV-2 coronavirus. Since then, the urgency for effective treatments resulted in unprecedented efforts to develop new vaccines and to accelerate the drug discovery pipeline, mainly through the repurposing of well-known compounds with broad antiviral effects. In particular, antiparasitic drugs historically used against human infections due to protozoa or helminth parasites have entered the main stage as a miracle cure in the fight against SARS-CoV-2. Despite having demonstrated promising anti-SARS-CoV-2 activities in vitro, conflicting results have made their translation into clinical practice more difficult than expected. Since many studies involving antiparasitic drugs are currently under investigation, the window of opportunity might be not closed yet. Here, we will review the (controversial) journey of these old antiparasitic drugs to combat the human infection caused by the novel coronavirus SARS-CoV-2.

Indexed as

anthelminticsantimalarialsantiparasiticsCOVID-19drug repurposingSARS-CoV-2

Identifiers

PMID35889004
PMCPMC9320270
OpenAlexW4283574286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.