Evidence mapPaperPMID 35890274Full record

ReviewPharmaceutics2022

Peptide-Based Bioconjugates and Therapeutics for Targeted Anticancer Therapy.

Seong-Bin Yang, Nipa Banik, Bomin Han, Dong-Nyeong Lee, Jooho Park

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  20. ATheranostics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Seong-Bin YangDepartment of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Korea.
Nipa BanikDepartment of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Korea.ORCID 0000-0001-5755-7086
Bomin HanDepartment of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Korea.
Dong-Nyeong LeeDepartment of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Korea.
Jooho ParkDepartment of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Korea.ORCID 0000-0001-6332-3278
Konkuk University · KR

Funding

Regional Innovation Strategy (RIS) 2021RIS-001Research Foundation of Korea(NRF) NRF-2020R1A2C1102831
6 · The paper itself

Abstract

With rapidly growing knowledge in bioinformatics related to peptides and proteins, amino acid-based drug-design strategies have recently gained importance in pharmaceutics. In the past, peptide-based biomedicines were not widely used due to the associated severe physiological problems, such as low selectivity and rapid degradation in biological systems. However, various interesting peptide-based therapeutics combined with drug-delivery systems have recently emerged. Many of these candidates have been developed for anticancer therapy that requires precisely targeted effects and low toxicity. These research trends have become more diverse and complex owing to nanomedicine and antibody-drug conjugates (ADC), showing excellent therapeutic efficacy. Various newly developed peptide-drug conjugates (PDC), peptide-based nanoparticles, and prodrugs could represent a promising therapeutic strategy for patients. In this review, we provide valuable insights into rational drug design and development for future pharmaceutics.

Indexed as

anticancer therapybioconjugatedrug conjugatedrug designpeptideprodrug

Identifiers

PMID35890274
PMCPMC9320687
OpenAlexW4283723774

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.