Evidence map›Paper›PMID 35891793›Full record

ArticleComputational and structural biotechnology journal2022

PP2A is activated by cytochrome

Miguel Á Casado-Combreras, Francisco Rivero-Rodríguez, Carlos A Elena-Real, Dmitry Molodenskiy, Antonio Díaz-Quintana, Marlène Martinho, Guillaume Gerbaud, Katiuska González-Arzola, Adrián Velázquez-Campoy, Dmitri Svergun and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. CytochromeiScience · 2024
    Article
  4. Article
  5. Mitochondrial Factors in the Cell Nucleus.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Miguel Á Casado-CombrerasInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Francisco Rivero-RodríguezInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Carlos A Elena-RealInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Dmitry MolodenskiyEuropean Molecular Biology Laboratory, Hamburg Outstation, c/o Deutsches Elektronen-Synchrotron, Notkestr. 85, 22607 Hamburg, Germany.
Antonio Díaz-QuintanaInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Marlène MartinhoAix Marseille Univ. Centre National de la Recherche Scientifique (CNRS), BIP UMR7281, Bioénergétique et Ingénierie des protéines, 13402 Marseille, France.
Guillaume GerbaudAix Marseille Univ. Centre National de la Recherche Scientifique (CNRS), BIP UMR7281, Bioénergétique et Ingénierie des protéines, 13402 Marseille, France.
Katiuska González-ArzolaInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Adrián Velázquez-CampoyInstitute of Biocomputation and Physic of Complex Systems (BIFI), Joint Unit GBsC-CSIC-BIFI, Universidad de Zaragoza. C. de Mariano Esquillor Gómez, Edificio I+D, 50018 Zaragoza, Spain.
Dmitri SvergunEuropean Molecular Biology Laboratory, Hamburg Outstation, c/o Deutsches Elektronen-Synchrotron, Notkestr. 85, 22607 Hamburg, Germany.
Valérie BelleAix Marseille Univ. Centre National de la Recherche Scientifique (CNRS), BIP UMR7281, Bioénergétique et Ingénierie des protéines, 13402 Marseille, France.
Miguel A De la RosaInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Irene Díaz-MorenoInstitute for Chemical Research (IIQ), Scientific Research Centre "Isla de la Cartuja" (cicCartuja), University of Seville and CSIC, Avda. Américo Vespucio, 49, 41092 Seville, Spain.
Centro de Investigaciones Científicas Isla de la Cartuja · ESCentre National de la Recherche Scientifique · FRDeutsches Elektronen-Synchrotron DESY · DEUniversidad de Zaragoza · ES

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ensemble of complexes, and the phenomenon is essential for the understanding of numerous biological processes. These conformational ensembles-encounter complexes-lack a unique organization, which prevents the determination of well-defined high resolution structures. This is the case for complexes involving the oncoprotein SET/template-activating factor-Iβ (SET/TAF-Iβ), a histone chaperone whose functions and interactions are significantly affected by its intrinsic structural plasticity. Besides its role in chromatin remodeling, SET/TAF-Iβ is an inhibitor of protein phosphatase 2A (PP2A), which is a key phosphatase counteracting transcription and signaling events controlling the activity of DNA damage response (DDR) mediators. During DDR, SET/TAF-Iβ is sequestered by cytochrome

Indexed as

ANP32B, Acidic leucine-rich nuclear phosphoprotein family member BBTFA, 3-bromo-1,1,1-trifluoroacetoneCc, Cytochrome cCD, Circular dichroismCDK9, Cyclin-dependent kinase 9CW, Continuous waveCytochrome cDDR, DNA damage responseDEER, Double electron–electron resonanceDLS, Dynamic light scatteringDmax, Maximum dimensionDMEM, Dulbecco’s modified Eagle’s mediumDNA, Deoxyribonucleic acidDTT, DithiotreitolEDTA, Ethylenediamine tetraacetic acidEGTA, Ethyleneglycol tetraacetic acidEncounter complexEPR, Electron paramagnetic resonanceFBS, Fetal bovine serumGUI, Graphical user interfaceHEK, Human embryonic kidney cellsHRP, Horseradish peroxidaseI2PP2A, Inhibitor 2 of the protein phosphatase 2AI3PP2A, Inhibitor 3 of the protein phosphatase 2AINTAC, Integrator-PP2A complexIp/Id, Intensity ratio of NMR resonances between paramagnetic and diamagnetic samplesIPTG, Isopropyl-β-D-1-thiogalactopyranosideITC, Isothermal titration calorimetryLB, Luria-BertaniMD, Molecular dynamicsMolecular dynamicsMTS, (1-acetoxy-2,2,5,5-tetramethyl-δ-3-pyrroline-3-methyl) methanethiosulfonateMTSL, (1-oxyl-2,2,5,5-tetramethyl- δ −3-pyrroline-3-methyl) methanethiosulfonateMW, Molecular weightNAP1, Nucleosome assembly protein 1NAPL, Nucleosome assembly protein LNMA, Normal mode analysisNMR, Nuclear magnetic resonanceNPT, Constant number, pressure and temperatureNuclear magnetic resonanceNVT, Constant number, volume and temperatureOD600, Optical density measured at 600 nmOPC, Optimal 3-charge, 4-point rigid water modelPCR, Polymerase chain reactionPME, Particle mesh EwaldPMSF, Phenylmethylsulfonyl fluoridePP2A, Protein phosphatase 2APRE, Paramagnetic relaxation enhancementProtein phosphatase 2APVDF, Polyvinylidene fluorideRg, Radius of gyrationRNApol II, RNA polymerase IIRNA, Ribonucleic acidSAXS, Small-angle X-ray scatteringSC, Sample changerSDSL, Site-directed spin labelingSDS-PAGE, Sodium dodecylsulfate-polyacrylamide gel electrophoresisSEC, Size-exclusion chromatographySET/TAF-IβSET/TAF-Iβ, SET/template-activating factor-IβSET/TAF-Iβ ΔC, SET/template-activating factor-Iβ construct lacking its C-terminal domainSPRi, Surface plasmon resonance imagingTAF-Iα, Template-activating factor-IαTPBS, Tween 20-phosphate buffered salineVPS75, Vacuolar protein sorting-associated protein 75WT, Wild typeXRD, X-ray diffraction

Identifiers

PMID35891793
PMCPMC9293736
OpenAlexW4284960041

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.