Evidence map›Paper›PMID 35896011›Full record

ArticleAging2022

Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.

Kexin Zhang, Jian Zhou, Tong Wu, Qunyan Tian, Tang Liu, Wanchun Wang, Hua Zhong, Ziyuan Chen, Xungang Xiao, Gen Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Kexin ZhangDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Jian ZhouDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Tong WuDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Qunyan TianDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Tang LiuDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Wanchun WangDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Hua ZhongDepartment of Orthopedics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510900, Guangdong, China.
Ziyuan ChenDepartment of Orthopedics, The First People's Hospital of Changde City, Changde 415003, Hunan, China.
Xungang XiaoDepartment of Orthopedics, Chenzhou No.1 People's Hospital, Chenzhou 423000, Hunan, China.
Gen WuDepartment of Orthopedics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510900, Guangdong, China.
Second Xiangya Hospital of Central South University · CNSouthern Medical University · CNCentral South University · CNChenzhou First People's Hospital · CNThe First People's Hospital of Changde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was undertaken to explore the expression and prognostic value of GINS family in human sarcoma, as well as the association between the expression levels of the GINS family and sarcoma immune infiltration.

resultsWe discovered that the mRNA expression levels of GINS1, GINS2, GINS3, and GINS4 were all higher in the majority of tumor tissues than in normal samples, of course, including sarcoma. Through the CCLE, all the four members expression were observed in high levels in sarcoma cell lines. In Gene Expression Profiling Analysis (GEPIA) and Kaplan-Meier Plotter, our results indicated that the poor overall survival (OS), disease-free survival (DFS) and relapse free survival (RFS) were tightly associated with the increased expression of GINS genes. In TIMER database, we found that highly expressed GINS was significantly correlated with the low infiltration level of CD4+ T cell and macrophage.

conclusionsThe four GINS family members were all the prognostic biomarkers for the prognosis of human sarcoma and can reduce the level of immune cell infiltration in the sarcoma microenvironment.

methodsIn terms of the expression levels of mRNA for GINS family members, a particular contrast in various cancers, especially human sarcoma, was conducted through ONCOMINE and GEPIA and CCLE databases. Kaplan-Meier Plotter was used to identify the prognostic value of GINS family in sarcoma. The relationship between the expression level of GINS and the infiltration of immune cells was analyzed in TIMER database.

Indexed as

Liver NeoplasmsSarcomaBiomarkers, TumorChromosomal Proteins, Non-HistoneDNA-Binding ProteinsHumansNeoplasm Recurrence, LocalPrognosisRNA, MessengerTumor MicroenvironmentBiomarkers, TumorChromosomal Proteins, Non-HistoneDNA-Binding ProteinsGINS1 protein, humanGINS2 protein, humanGINS3 protein, humanGINS4 protein, humanRNA, Messengerexpression levelGINSprognosissarcoma

Identifiers

PMID35896011
PMCPMC9365567
OpenAlexW4288052601

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.