ArticleSignal transduction and targeted therapy2022
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl
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Article in Signal transduction and targeted therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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0cells of the map it votes in
30citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
What it found
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- CFTR mediates ClNature communications · 2026Article
- Polyglutamine-Expanded Ataxin-3 Accelerates CFTR Degradation Through K63-Linked Ubiquitination to Exacerbate Microglial Inflammation.ASN neuro · 2026Article
- Phosphorylation Changes SARS-CoV-2 Nucleocapsid Protein's Structural Dynamics and Its Interaction With RNA.Proteins · 2025Article
- SARS-CoV-2 N protein induces hypokalemia in acute kidney injury mice via ENaC-dependent mechanism.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Screening and identification of host factors interacting with the nucleocapsid protein of SARS-CoV-2 omicron variant using the yeast two-hybrid system.BMC microbiology · 2025Article
- Review
- Exploring serum and glucocorticoid-regulated kinase 1: A promising target for COVID-19 and atrial fibrillation treatment.Heart rhythm O2 · 2025Review
- iPSC-derived human cortical organoids display profound alterations of cellular homeostasis following SARS-CoV-2 infection and Spike protein exposure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- A comprehensive review of current insights into the virulence factors of SARS-CoV-2.Journal of virology · 2025Review
- SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis.The Journal of cell biology · 2025Article
- Intrinsic factors behind long COVID: exploring the role of nucleocapsid protein in thrombosis.PeerJ · 2025Review
- A20 as a Potential Therapeutic Target for COVID-19.Immunity, inflammation and disease · 2025Review
- A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers.Frontiers in immunology · 2025Article
- Linoleic acid inhibits lipopolysaccharide-induced inflammation by promoting TLR4 regulated autophagy in murine RAW264.7 macrophages.Journal of applied biomedicine · 2024Article
- An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo.Virologica Sinica · 2024Article
- Diverse roles of SARS-CoV-2 Spike and Nucleocapsid proteins in EndMT stimulation through the TGF-β-MRTF axis inhibited by aspirin.Cell communication and signaling : CCS · 2024Article
- Beyond Borders of the Cell: How Extracellular Vesicles Shape COVID-19 for People with Cystic Fibrosis.International journal of molecular sciences · 2024Review
- SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular ClSignal transduction and targeted therapy · 2024Article
- Chloride salt enhances plant resistance to biotic stresses.Frontiers in plant science · 2024Article
- Multifaceted role of SARS-CoV-2 structural proteins in lung injury.Frontiers in immunology · 2024Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Lei Chen *School of Life Sciences, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-9488-1173
Wei-Jie Guan *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zhuo-Er Qiu *School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Jian-Bang Xu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Xu BaiSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Xiao-Chun HouSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Jing SunState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Su QuSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Ze-Xin HuangSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Tian-Lun LeiSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Zi-Yang HuangSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Jincun ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-2515-5589
Yun-Xin ZhuSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Ke-Nan YeSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Zhao-Rong LunSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Wen-Liang ZhouSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China. lsszwl@mail.sysu.edu.cn.ORCID 0000-0001-9124-3144
Nan-Shan ZhongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China. nanshan@vip.163.com.
Yi-Lin ZhangSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China. zhangylin9@mail.sysu.edu.cn.ORCID 0000-0001-5350-8279
Sun Yat-sen University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNGuangzhou Experimental Station · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune responses and cytokine storms. Intracellular Cl
Indexed as
COVID-19MicroRNAsAnimalsChlorineHumansInflammationMiceNucleocapsid ProteinsRespiratory MucosaSARS-CoV-2ChlorineMicroRNAsMIRN145 microRNA, humanNucleocapsid Proteins
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.