ArticleThe ISME journal2022
Amino acid utilization allows intestinal dominance of Lactobacillus amylovorus.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Effects of Dietary Protein and Starch Digestion Rates on Jejunal and Cecal Microbial Community States and Feed Efficiency in Raccoon Dogs.Animals : an open access journal from MDPI · 2026Article
- Galacto-Oligosaccharides Reshape MucinJournal of agricultural and food chemistry · 2026Article
- Dietary regulation on gut resistome linked with microbial amino acid metabolism in pigs.Animal microbiome · 2026Article
- Multi-omics and network pharmacology reveal the mechanisms of Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang against pancreatic cancer.Scientific reports · 2026Article
- Lactic Acid Bacteria for Fungal Control and Shelf-Life Extension in Fresh Pasta: Mechanistic Insights and Clean-Label Strategies.Molecules (Basel, Switzerland) · 2026Review
- Spatiotemporal dynamics of mucosa-associatedAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Oxidative Stress Model of Lipopolysaccharide-Challenge in Piglets of Wuzhishan Miniature Pig.Veterinary sciences · 2025Article
- Multi-Strain Probiotics Alleviate Food Allergy-Induced Neurobehavioral Abnormalities by Regulating Gut Microbiota and Metabolites.Nutrients · 2025Article
- OVA-Induced Food Allergy Leads to Neurobehavioral Changes in Mice and the Potential Role of Gut Microbiota and Metabolites Dysbiosis.International journal of molecular sciences · 2025Article
- Metatranscriptomics for Understanding the Microbiome in Food and Nutrition Science.Metabolites · 2025Review
- Enhancing nutrient efficiency through optimizing protein levels in lambs: Involvement of gastrointestinal microbiota.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
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- Ensiling characteristics,Frontiers in plant science · 2025Article
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- Gut bacteria facilitate leaf beetles in adapting to dietary specialization by enhancing larval fitness.NPJ biofilms and microbiomes · 2024Article
- IntestinalProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Pathway and Production Differences in Branched-Chain Hydroxy Acids as Bioactive Metabolites inInternational journal of molecular sciences · 2024Article
- Breed-Driven Microbiome Heterogeneity Regulates Intestinal Stem Cell Proliferation via Lactobacillus-Lactate-GPR81 Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mucin alleviates colonic barrier dysfunction by promoting spermine accumulation through enhanced arginine metabolism inmSystems · 2024Article
- Dose-Responsive Effects of Iron Supplementation on the Gut Microbiota in Middle-Aged Women.Nutrients · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The mammalian intestine harbors heterogeneous distribution of microbes among which specific taxa (e.g. Lactobacillus) dominate across mammals. Deterministic factors such as nutrient availability and utilization may affect microbial distributions. Due to physiological complexity, mechanisms linking nutrient utilization and the dominance of key taxa remain unclear. Lactobacillus amylovorus is a predominant species in the small intestine of pigs. Employing a pig model, we found that the small intestine was dominated by Lactobacillus and particularly L. amylovorus, and enriched with peptide-bound amino acids (PBAAs), all of which were further boosted after a peptide-rich diet. To investigate the bacterial growth dominance mechanism, a representative strain L. amylovorus S1 was isolated from the small intestine and anaerobically cultured in media with free amino acids or peptides as sole nitrogen sources. L. amylovorus S1 grew preferentially with peptide-rich rather than amino acid-rich substrates, as reflected by enhanced growth and PBAA utilization, and peptide transporter upregulations. Utilization of free amino acids (e.g. methionine, valine, lysine) and expressions of transporters and metabolic enzymes were enhanced simultaneously in peptide-rich substrate. Additionally, lactate was elevated in peptide-rich substrates while acetate in amino acid-rich substrates, indicating distinct metabolic patterns depending on substrate forms. These results suggest that an increased capability of utilizing PBAAs contributes to the dominance of L. amylovorus, indicating amino acid utilization as a deterministic factor affecting intestinal microbial distribution. These findings may provide new insights into the microbe-gut nutrition interplay and guidelines for dietary manipulations toward gut health especially small intestine health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.