Evidence map›Paper›PMID 35897685›Full record

ReviewInternational journal of molecular sciences2022

Role of Diet in Stem and Cancer Stem Cells.

Francesca Puca, Monica Fedele, Debora Rasio, Sabrina Battista

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francesca PucaDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 78705, USA.ORCID 0000-0002-1974-3424
Monica FedeleInstitute for Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131 Naples, Italy.ORCID 0000-0002-9171-1312
Debora RasioDepartment of Clinical and Molecular Medicine, La Sapienza University, 00185 Rome, Italy.
Sabrina BattistaInstitute for Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131 Naples, Italy.ORCID 0000-0001-5899-9759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet and lifestyle factors greatly affect health and susceptibility to diseases, including cancer. Stem cells' functions, including their ability to divide asymmetrically, set the rules for tissue homeostasis, contribute to health maintenance, and represent the entry point of cancer occurrence. Stem cell properties result from the complex integration of intrinsic, extrinsic, and systemic factors. In this context, diet-induced metabolic changes can have a profound impact on stem cell fate determination, lineage specification and differentiation. The purpose of this review is to provide a comprehensive description of the multiple "non-metabolic" effects of diet on stem cell functions, including little-known effects such as those on liquid-liquid phase separation and on non-random chromosome segregation (asymmetric division). A deep understanding of the specific dietetic requirements of normal and cancer stem cells may pave the way for the development of nutrition-based targeted therapeutic approaches to improve regenerative and anticancer therapies.

Indexed as

NeoplasmsNeoplastic Stem CellsCell DifferentiationChromosome SegregationDietHomeostasisasymmetric divisionautophagycaloric restrictioncancer stem cellsdietmTORnutrientsSIRT1stem cells

Identifiers

PMID35897685
PMCPMC9330301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.