Evidence map›Paper›PMID 35897712›Full record

ArticleInternational journal of molecular sciences2022

Isolated Variable Domains of an Antibody Can Assemble on Blood Coagulation Factor VIII into a Functional Fv-like Complex.

Svetlana A Shestopal, Leonid A Parunov, Philip Olivares, Haarin Chun, Mikhail V Ovanesov, John R Pettersson, Andrey G Sarafanov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Svetlana A ShestopalCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0003-0725-5885
Leonid A ParunovCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0002-8892-8908
Philip OlivaresCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0003-3182-5884
Haarin ChunCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0002-2668-6296
Mikhail V OvanesovCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0003-2509-1781
John R PetterssonCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0002-7072-3576
Andrey G SarafanovCenter for Biologics Evaluation and Research, U. S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0001-6124-9713
Center for Biologics Evaluation and Research · US

Funding

United States Food and Drug Administration CBER, project 05010
6 · The paper itself

Abstract

Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (V

Indexed as

Factor VIIISingle-Chain AntibodiesAntigensBaculoviridaeLow Density Lipoprotein Receptor-Related Protein-1ThrombinAntigensFactor VIIILow Density Lipoprotein Receptor-Related Protein-1Single-Chain AntibodiesThrombinantibody engineeringcoagulation factor VIIIlow-density lipoprotein receptor-related protein 1single-chain variable fragmentthrombin

Identifiers

PMID35897712
PMCPMC9330781
OpenAlexW4287010025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.