ReviewMolecules (Basel, Switzerland)2022
Advances on Natural Abietane, Labdane and Clerodane Diterpenes as Anti-Cancer Agents: Sources and Mechanisms of Action.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Anticancer activity of amide and ester derivatives of the ent-labdane 2α-hydroxyeperuic acid obtained via sonochemical synthesis.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Carnosic Acid and Its Semisynthetic Derivatives as Promising Anticancer Agents.International journal of molecular sciences · 2026Review
- Uncovering the gastroprotective properties of araucaria brown propolis and its active compound, abietic acid.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Antioxidant and Anticancer Activities of Water Extracts from Flowers, Leaves and Stems of In Vitro Cultivated and Wild-GrowingPharmaceuticals (Basel, Switzerland) · 2025Article
- Re-sensitization of cancer multidrug resistance through P-gp, MRP1 and BCRP modulation: advances in terpenoids based cancer therapy.Discover oncology · 2025Review
- Synthesis and biological evaluation of novel carnosic acid derivatives with anticancer activity.RSC advances · 2025Article
- Tissue-Specific Enhancement of Insulin Function and Restoration of Glucose-Stimulated Insulin Secretion byPharmaceuticals (Basel, Switzerland) · 2025Article
- Bidah Pomegranate Landrace: Chemical Composition, Antioxidant, Antibacterial, and Anticancer Activity.Life (Basel, Switzerland) · 2025Article
- Design, Synthesis, and Biological Evaluation of Novel Urea-Containing Carnosic Acid Derivatives with Anticancer Activity.International journal of molecular sciences · 2024Article
- Metabolomic insights and bioactive efficacies ofHeliyon · 2024Article
- A First Metabolite Analysis of Norfolk Island Pine Resin and Its Hepatoprotective Potential to Alleviate Methotrexate (MTX)-Induced Hepatic Injury.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Characterization of Terpenoids from the Ambrosia Beetle Symbiont and Laurel Wilt PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- Extending the Structural Diversity of Labdane Diterpenoids from Marine-Derived FungusMarine drugs · 2023Article
- Enantioselective and collective total synthesis of pentacyclic 19-Chemical science · 2023Article
- Natural Compounds and Glutathione: Beyond Mere Antioxidants.Antioxidants (Basel, Switzerland) · 2023Review
- Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells.Journal of cancer research and clinical oncology · 2023Article
- Anti-Inflammatory and Cytotoxic Activities of Clerodane-Type Diterpenes.Molecules (Basel, Switzerland) · 2023Review
- Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide.Plants (Basel, Switzerland) · 2023Review
- Bioactive Clerodane Diterpenoids from the Leaves ofMolecules (Basel, Switzerland) · 2023Article
- Production of secondary metabolites using tissue culture-based biotechnological applications.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive research over the past decades has identified numerous phytochemicals that could represent an important source of anti-cancer compounds. There is an immediate need for less toxic and more effective preventive and therapeutic strategies for the treatment of cancer. Natural compounds are considered suitable candidates for the development of new anti-cancer drugs due to their pleiotropic actions on target events with multiple manners. This comprehensive review highlighted the most relevant findings achieved in the screening of phytochemicals for anticancer drug development, particularly focused on a promising class of phytochemicals such as diterpenes with abietane, clerodane, and labdane skeleton. The chemical structure of these compounds, their main natural sources, and mechanisms of action were critically discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.