Evidence map›Paper›PMID 35900007›Full record

ArticleSchizophrenia bulletin2022

Maternal Schizophrenia and the Risk of a Childhood Chronic Condition.

Simone N Vigod, Joel G Ray, Eyal Cohen, Andrew S Wilton, Natasha R Saunders, Lucy C Barker, Anick Berard, Cindy-Lee Dennis, Alison C Holloway, Katherine Morrison and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simone N VigodWomen's College Hospital and Women's College Research Institute, Toronto, ON, Canada.ORCID 0000-0002-2736-9639
Joel G RayInstitute for Health Policy, Management and Evaluation, Toronto, ON, Canada.
Eyal CohenInstitute for Health Policy, Management and Evaluation, Toronto, ON, Canada.
Andrew S WiltonICES, Toronto, ON, Canada.
Natasha R SaundersInstitute for Health Policy, Management and Evaluation, Toronto, ON, Canada.
Lucy C BarkerWomen's College Hospital and Women's College Research Institute, Toronto, ON, Canada.
Anick BerardUniversite de Montreal, Faculty of Pharmacy, Montreal, QC, Canada.
Cindy-Lee DennisWomen's College Hospital and Women's College Research Institute, Toronto, ON, Canada.
Alison C HollowayDepartment of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-4343-5325
Katherine MorrisonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Tim F OberlanderDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Gillian HanleyDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Karen TuInstitute for Health Policy, Management and Evaluation, Toronto, ON, Canada.
Hilary K BrownWomen's College Hospital and Women's College Research Institute, Toronto, ON, Canada.ORCID 0000-0002-8690-5841

Funding

CIHR PJT156021
6 · The paper itself

Abstract

background and hypothesisMaternal schizophrenia heightens the risk for certain perinatal complications, yet it is not known to what degree future childhood chronic health conditions (Childhood-CC) might arise. STUDY

designThis population-based cohort study using health administrative data from Ontario, Canada (1995-2018) compared 5066 children of mothers with schizophrenia to 25 324 children of mothers without schizophrenia, propensity-matched on birth-year, maternal age, parity, immigrant status, income, region of residence, and maternal medical and psychiatric conditions other than schizophrenia. Cox proportional hazard models generated hazard ratios (HR) and 95% confidence intervals (CI) for incident Childhood-CCs, and all-cause mortality, up to age 19 years. STUDY

resultsSix hundred and fifty-six children exposed to maternal schizophrenia developed a Childhood-CC (20.5/1000 person-years) vs. 2872 unexposed children (17.1/1000 person-years)-an HR of 1.18, 95% CI 1.08-1.28. Corresponding rates were 3.3 vs. 1.9/1000 person-years (1.77, 1.44-2.18) for mental health Childhood-CC, and 18.0 vs. 15.7/1000 person-years (1.13, 1.04-1.24) for non-mental health Childhood-CC. All-cause mortality rates were 1.2 vs. 0.8/1000 person-years (1.34, 0.96-1.89). Risk for children exposed to maternal schizophrenia was similar whether or not children were discharged to social service care. From age 1 year, risk was greater for children whose mothers were diagnosed with schizophrenia prior to pregnancy than for children whose mothers were diagnosed with schizophrenia postnatally.

conclusionsA child exposed to maternal schizophrenia is at elevated risk of chronic health conditions including mental and physical subtypes. Future research should examine what explains the increased risk particularly for physical health conditions, and what preventive and treatment efforts are needed for these children.

Indexed as

SchizophreniaAdultChildChronic DiseaseCohort StudiesFemaleHumansInfantMothersOntarioPregnancyYoung AdultChild HealthPregnancySchizophrenia

Identifiers

PMID35900007
PMCPMC9673258

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.