Evidence map›Paper›PMID 35905825›Full record

ArticleActa biomaterialia2022

Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery.

Sergio A Pineda-Castillo, Santiago Aparicio-Ruiz, Madison M Burns, Devin W Laurence, Elizabeth Bradshaw, Tingting Gu, Gerhard A Holzapfel, Chung-Hao Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Sergio A Pineda-CastilloBiomechanics and Biomaterials Design Lab, School of Aerospace and Mechanical Engineering, The University of Oklahoma, USA; Stephenson School of Biomedical Engineering, The University of Oklahoma, USA.
Santiago Aparicio-RuizBiomechanics and Biomaterials Design Lab, School of Aerospace and Mechanical Engineering, The University of Oklahoma, USA.
Madison M BurnsBiomechanics and Biomaterials Design Lab, School of Aerospace and Mechanical Engineering, The University of Oklahoma, USA.
Devin W LaurenceBiomechanics and Biomaterials Design Lab, School of Aerospace and Mechanical Engineering, The University of Oklahoma, USA.
Elizabeth BradshawBiomechanics and Biomaterials Design Lab, School of Aerospace and Mechanical Engineering, The University of Oklahoma, USA.
Tingting GuSamuel Roberts Noble Microscopy Laboratory, The University of Oklahoma, USA.
Gerhard A HolzapfelInstitute of Biomechanics, Graz University of Technology, Austria; Department of Structural Engineering, Norwegian University of Science and Technology, Norway.
Chung-Hao LeeBiomechanics and Biomaterials Design Lab, School of Aerospace and Mechanical Engineering, The University of Oklahoma, USA. Electronic address: ch.lee@ou.edu.
University of Oklahoma · USBiomechanics Institute of Valencia · ESNorwegian University of Science and Technology · NO

Funding

Improving outcomes in endovascular treatment of intracranial aneurysms: Combining additive manufacturing, in-silico modeling, and shape memory polymersR01HL159475 · NHLBI · UNIVERSITY OF OKLAHOMA · PI Chung-Hao Lee · 2022 to 2026
$3.3M
NHLBI NIH HHS R01 HL159475
6 · The paper itself

Abstract

Coronary atherosclerosis is the main cause of death worldwide. Advancing the understanding of coronary microstructure-based mechanics is fundamental for the development of therapeutic tools and surgical procedures. Although the passive biaxial properties of the coronary arteries have been extensively explored, their regional differences and the relationship between tissue microstructure and mechanics have not been fully characterized. In this study, we characterized the passive biaxial mechanical properties and microstructural properties of the proximal, medial, and distal regions of the porcine left anterior descending artery (LADA). We also attempted to relate the biaxial stress-stretch response of the LADA and its respective birefringent responses to the polarized light for obtaining information about the load-dependent microstructural variations. We found that the LADA extensibility is reduced in the proximal-to-distal direction and that the medial region exhibits more heterogeneous mechanical behavior than the other two regions. We have also observed highly dynamic microstructural behavior where fiber families realign themselves depending on loading. In addition, we found that the microstructure of the distal region exhibited highly aligned fibers along the longitudinal axis of the artery. To verify this microstructural feature, we imaged the LADA specimens with multi-photon microscopy and observed that the adventitia microstructure transitioned from a random fiber network in the proximal region to highly aligned fibers in the distal region. Our findings could offer new perspectives for understanding coronary mechanics and aid in the development of tissue-engineered vascular grafts, which are currently limited due to their mismatch with native tissue in terms of mechanical properties and microstructural features. STATEMENT OF SIGNIFICANCE: The tissue biomechanics of coronary arteries is fundamental for the development of revascularization techniques such as coronary artery bypass. These therapeutics require a deep understanding of arterial mechanics, microstructure, and mechanobiology to prevent graft failure and reoperation. The present study characterizes the unique regional mechanical and microstructural properties of the porcine left anterior descending artery using biaxial testing, polarized-light imaging, and confocal microscopy. This comprehensive characterization provides an improved understanding of the collagen/elastin architecture in response to mechanical loads using a region-specific approach. The unique tissue properties obtained from this study will provide guidance for the selection of anastomotic sites in coronary artery bypass grafting and for the design of tissue-engineered vascular grafts.

Indexed as

CollagenHeartAdventitiaAnimalsBiomechanical PhenomenaCoronary VesselsStress, MechanicalSwineCollagenCollagen and elastin microstructureConstitutive modelingCoronary artery biomechanicsMulti-photon microscopyPlanar biaxial testingPolarized spatial frequency domain imaging

Identifiers

PMID35905825
PMCPMC10230544
OpenAlexW4288046657

What Socratic holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.