ArticleNeurobiology of disease2022
Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.
Open access · goldAbstract read
In one paragraph
Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Aquaporin-4 mislocalization from astrocyte endfeet prolongs survival in a prion-cerebral amyloid angiopathy model.bioRxiv : the preprint server for biology · 2026Article
- ESCRT-0 regulates AMPA receptor currents and CabioRxiv : the preprint server for biology · 2026Article
- PrPStem cell reports · 2026Article
- Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.PLoS pathogens · 2026Article
- Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.bioRxiv : the preprint server for biology · 2026Article
- Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.Acta neuropathologica communications · 2026Article
- Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models.Molecular autism · 2025Article
- Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.The Journal of clinical investigation · 2025Article
- Human Genetic Evidence for New Targets in Prion Diseases: Opportunities and Challenges.Sub-cellular biochemistry · 2025Review
- Limbic system synaptic dysfunctions associated with prion disease onset.Acta neuropathologica communications · 2024Article
- Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer's disease.Nature communications · 2024Article
- New Light on Prions: Putative Role of PrPInternational journal of molecular sciences · 2024Review
- Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Daniel Ojeda-JuárezDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Jessica A LawrenceDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Katrin SoldauDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Donald P PizzoDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Emily WheelerDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Patricia Aguilar-CalvoDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Helen KhuuDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Joy ChenDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Adela MalikDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Gail FunkDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Percival NamDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Henry SanchezDepartment of Pathology, Division of Neuropathology, University of California San Francisco, San Francisco, CA, USA.
Michael D GeschwindDepartment of Neurology, Weill Institute for Neurosciences, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Chengbiao WuDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Xu ChenDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Gentry N PatrickDivision of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA, USA.
Christina J SigurdsonDepartment of Pathology, University of California San Diego, La Jolla, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, USA; Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, CA, USA. Electronic address: csigurdson@health.ucsd.edu.
University of California, San Diego · USUniversity of California, San Francisco · US
Funding
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Subhojit Roy · 2019 to 2026
$34.9MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MPredicting progression of human prion diseaseR01AG031189 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2008 to 2017
$5.7MMechanisms of Prion Aggregation and Species BarriersR01NS069566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, RAVITS, JOHN · 2011 to 2025
$5.7MTracking longitudinal change in presymptomatic genetic prion disease (TLC-Pre-gPrD)R01AG062562 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2019 to 2023
$5.4MMechanisms of Prion SpreadR01NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2012 to 2021
$3.4MMechanisms of Prion Spread and Neuronal ToxicityR37NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christina Sigurdson · 2023 to 2026
$2.6MMolecular basis of prion protein-induced neurodegenerationRF1NS121992 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2021 to 2023
$1.7MMolecular basis of prion protein-induced neurodegenerationR01NS121992 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2024 to 2025
$963kTLC-Pre-gPrD: Tracking Longitudinal Change in Presymptomatic genetic Prion DiseaseR56AG055619 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2018 to 2018
$800kJEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579kTargeting vesicular transport pathways in prion diseaseF31NS103588 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAWRENCE, JESSICA ANNE · 2017 to 2019
$114kNIA NIH HHS P30 AG062429NIA NIH HHS R01 AG031189NIA NIH HHS R01 AG062562NIA NIH HHS R56 AG055619NIH HHS S10 OD023527NINDS NIH HHS F31 NS103588NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS069566NINDS NIH HHS R01 NS076896NINDS NIH HHS R01 NS121992NINDS NIH HHS R37 NS076896NINDS NIH HHS RF1 NS121992
Abstract
Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion protein (PrP
Indexed as
Creutzfeldt-Jakob SyndromePrionsAmyloid beta-PeptidesAnimalsHippocampusLongitudinal StudiesMaleMiceAmyloid beta-PeptidesPrionsAmyloidImmediate early genesmGluR5NeurodegenerationPrion disease
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.