Evidence map›Paper›PMID 35907121›Full record

ArticleJournal of physiology and biochemistry2022

Metformin induces mitochondrial remodeling and differentiation of pancreatic progenitor cells into beta-cells by a potential mechanism including suppression of the T1R3, PLCβ2, cytoplasmic Ca

Ertan Celik, Merve Ercin, Sehnaz Bolkent, Selda Gezginci-Oktayoglu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ertan CelikMolecular Biology Program, Biology Section, Institute of Science, Istanbul University, Istanbul, Turkey.
Merve ErcinMolecular Biology Program, Biology Section, Institute of Science, Istanbul University, Istanbul, Turkey.
Sehnaz BolkentMolecular Biology Section, Biology Department, Faculty of Science, Istanbul University, Vezneciler, 34134, Istanbul, Turkey.
Selda Gezginci-OktayogluMolecular Biology Section, Biology Department, Faculty of Science, Istanbul University, Vezneciler, 34134, Istanbul, Turkey. selgez@istanbul.edu.tr.ORCID http://orcid.org/0000-0002-1378-1585
Istanbul University · TR

Funding

Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi 26194Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi 52123Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 116Z560
6 · The paper itself

Abstract

The main goal of this study was to investigate the molecular changes in pancreatic progenitor cells subject to high glucose, aspartame, and metformin in vitro. This scope of work glucose, aspartame, and metformin were exposed to pancreatic islet derived progenitor cells (PID-PCs) for 10 days. GLUT1's role in beta-cell differentiation was examined by using GLUT1 inhibitor WZB117. Insulin

Indexed as

MetforminAspartameCell DifferentiationGlucoseGlucose Transporter Type 1InsulinMitochondriaPhospholipase C betaProto-Oncogene Proteins c-aktStem CellsAspartameGlucoseGlucose Transporter Type 1InsulinMetforminPhospholipase C betaProto-Oncogene Proteins c-aktAspartameBeta-cell differentiationGlucose metabolismMetforminMitochondrial remodelingPancreatic progenitor cells

Identifiers

PMID35907121
OpenAlexW4288902688

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.