ArticleCell2022
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Open access · greenAbstract read
In one paragraph
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 2 pooled it
28.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
218 citing papers in PubMed, 2 syntheses or guidelines pooled it, 355 citations in OpenAlex.
- Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting.CNS neuroscience & therapeutics · 2026Pooled it
- Mitochondria: a breakthrough in combating rheumatoid arthritis.Frontiers in medicine · 2024Pooled it
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma.Signal transduction and targeted therapy · 2026Article
- The factory enters the fray: how mitochondrial protein trafficking shapes the host response to infection.Journal of virology · 2026Review
- Precision inflammation targeting via myeloperoxidase mediated antioxidant melanin nanomedicines for chronic inflammation therapy.Nature communications · 2026Article
- The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.Cellular & molecular immunology · 2026Article
- Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review).Molecular medicine reports · 2026Review
- Deciphering the rules of regulated cell death subroutines by in silico methods.Journal of advanced research · 2026Review
- AMPK as a central regulator of necroptosis: mechanistic insights and therapeutic implications.Journal of physiology and biochemistry · 2026Review
- Ac-SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes.Animal models and experimental medicine · 2026Article
- Source-Dependent Mitochondrial Transplantation Drives Schwann Cell Bioenergetic Reprogramming and Peripheral Nerve Regeneration.Advanced healthcare materials · 2026Article
- Mitochondria-Targeted Photodynamic Agents Drive Robust Pyroptosis by Caspase-3/GSDME Activation and Cardiolipin Externalization.Angewandte Chemie (International ed. in English) · 2026Article
- Review
- Gasdermin D in Neurodegenerative Diseases: Pathogenic Roles and Therapeutic Perspectives.Molecular neurobiology · 2026Review
- Macrophage extracellular traps accelerate atherosclerosis progression via Rap1 pathway-mediated necroptosis and phenotypic switching in vascular smooth muscle cells.Journal of translational medicine · 2026Article
- Redox-modulation of regulated cell death: implications for synergistic anticancer therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Mitochondrial STAT3-mediated suppression of apoptosis constrains antimycobacterial immunity.bioRxiv : the preprint server for biology · 2026Article
- The Role of Apoptosis and Ferroptosis in Primary Mitochondrial Diseases: Mechanisms and Pathogenesis.International journal of molecular sciences · 2026Review
- Yam glycoprotein mediated the immunomodulation of macrophages by targeting TLR4.Molecular biology reports · 2026Article
158 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Chi G WeindelDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Eduardo L MartinezDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Xiao ZhaoDepartment of Molecular and Cellular Medicine, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Cory J MabryDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Samantha L BellDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA; Department of Microbiology, Biochemistry & Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Krystal J VailDepartment of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences, College Station, TX 77843, USA; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Aja K ColemanDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Jordyn J VanPortflietDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Baoyu ZhaoDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
Allison R WagnerDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Sikandar AzamDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Haley M ScottDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Pingwei LiDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
A Phillip WestDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Jason KarpacDepartment of Molecular and Cellular Medicine, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA.
Kristin L PatrickDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA. Electronic address: kpatrick03@tamu.edu.
Robert O WatsonDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA. Electronic address: robert.watson@tamu.edu.
Texas A&M Health Science Center · USTexas A&M University · USRutgers, The State University of New Jersey · USTulane University · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MComparative Biomedical Research Training for VeterinariansT32OD011083 · OD · TEXAS A&M AGRILIFE RESEARCH · PI ALBERT MULENGA · 2012 to 2026
$4.8MMitochondria as crucial regulators of innate immune outcomes during Mycobacterium tuberculosis infectionR01AI155621 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATRICK, KRISTIN LEIGH, WATSON, ROBERT OWEN · 2021 to 2025
$2.9MType I Interferon Responses in the Pathobiology of Anthracycline-induced CardiotoxicityR01HL148153 · NHLBI · TEXAS A&M UNIVERSITY · PI John Travis Hinson, Andrew Phillip West · 2020 to 2026
$2.8MMolecular basis of viral DNA sensing through the cGAS-STING pathwayR01AI145287 · NIAID · TEXAS A&M AGRILIFE RESEARCH · PI Pingwei Li · 2019 to 2026
$2.5MFoxo/NFkB Interactions in the Regulation of Metabolic HomeostasisR01DK108930 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI KARPAC, JASON S · 2016 to 2020
$1.7MIMSD at Texas A&M University: Initiative for Maximizing Student Diversity in Biomedical SciencesT32GM135748 · NIGMS · TEXAS A&M UNIVERSITY · PI BRINKMEYER-LANGFORD, CANDICE L., CHIU, WEIHSUEH A · 2020 to 2024
$1.2MDiet-NFkB interactions in the transcriptional regulation of metabolic homeostasisR56DK108930 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI KARPAC, JASON S · 2021 to 2021
$186kNHLBI NIH HHS R01 HL148153NIAID NIH HHS R01 AI145287NIAID NIH HHS R01 AI155621NIDDK NIH HHS R01 DK108930NIDDK NIH HHS R56 DK108930NIGMS NIH HHS T32 GM135748NIH HHS P51 OD011104NIH HHS T32 OD011083
Abstract
Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele Lrrk2
Indexed as
MitochondriaNecroptosisAnimalsGasderminsHumansInflammasomesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MacrophagesMicePhosphate-Binding ProteinsPore Forming Cytotoxic ProteinsReactive Oxygen SpeciesGasderminsGsdmd protein, mouseInflammasomesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Phosphate-Binding ProteinsPore Forming Cytotoxic ProteinsReactive Oxygen SpeciesDrosophila melanogasterimmunometabolisminflammasomeinflammationinnate immunityLRRK2Mycobacterium tuberculosisParkinson’s diseasepyroptosisRIPK3
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.