Evidence map›Paper›PMID 35908177›Full record

ArticleThe international journal of neuropsychopharmacology2022

D2/D3 Receptor Agonism: Paving the Way for a New Therapeutic Target for Taste Disorders in Parkinson's Disease and Other Conditions?

Elisa Mantovani, Stefano Tamburin

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elisa MantovaniDepartment of Neurosciences, Biomedicine and Movement Sciences, Neurology Section, University of Verona, Italy.ORCID 0000-0003-3717-7697
Stefano TamburinDepartment of Neurosciences, Biomedicine and Movement Sciences, Neurology Section, University of Verona, Italy.ORCID 0000-0002-1561-2187
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemosensory (i.e., olfaction and taste) dysfunction is common in neurodegenerative (e.g., Parkinson's disease, Alzheimer's disease, and dementia), psychiatric (e.g., depression, bipolar disorders, other conditions), and postinfectious (i.e., long COVID) diseases and in the elderly. Despite its impact on patients' quality of life, no established treatment for taste disorders exists so far. A recent report on the effect of pramipexole, a D2/D3 agonist, on taste performance in healthy participants provides support for a new potential therapeutic target for taste dysfunction to be tested in future randomized, placebo-controlled, clinical trials across several populations reporting gustatory symptoms.

Indexed as

COVID-19Parkinson DiseaseAgedBenzothiazolesDopamineDopamine AgonistsHealthy VolunteersHumansPost-Acute COVID-19 SyndromePramipexoleQuality of LifeReceptors, Dopamine D3TasteTaste DisordersBenzothiazolesDopamineDopamine AgonistsPramipexoleReceptors, Dopamine D3D2/D3 receptor agonismParkinson’s diseasepramipexoletaste disorderstreatment

Identifiers

PMID35908177
PMCPMC9670739
OpenAlexW4288913936

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.