Evidence map›Paper›PMID 35908311›Full record

ReviewCurrent opinion in virology2022

Viral-host interactions during splicing and nuclear export of influenza virus mRNAs.

Matthew Esparza, Prasanna Bhat, Beatriz Ma Fontoura

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  7. Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. Review
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  19. Negative and ambisense RNA virus ribonucleocapsids: more than protective armor.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew EsparzaDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Prasanna BhatDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Beatriz Ma FontouraDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: beatriz.fontoura@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

Splicing and Nuclear Transport of Influenza Virus mRNAR01AI125524 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI COBB, MELANIE H., FONTOURA, BEATRIZ MA · 2016 to 2025
$5.6M
Virulence Factor at the Interface of Viral and Cellular mRNA Nuclear ExportR01AI154635 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Beatriz MA Fontoura · 2020 to 2026
$5.1M
NIAID NIH HHS R01 AI125524NIAID NIH HHS R01 AI154635
6 · The paper itself

Abstract

As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by export from the nucleus. The focus of this review is on viral RNA splicing and nuclear export. Recent mechanistic advances on M and NS splicing show differential regulation by RNA-binding proteins as well as distinct intranuclear localization. After a review of IAV splicing, we will discuss the nuclear export of viral mRNAs, which occur by interacting with specific constituents of the host mRNA export machinery that translocate viral mRNAs through the nuclear pore complex for translation in the cytoplasm.

Indexed as

Host Microbial InteractionsInfluenza A virusActive Transport, Cell NucleusCell NucleusRNA, MessengerRNA SplicingRNA, ViralVirus ReplicationRNA, MessengerRNA, Viral

Identifiers

PMID35908311
PMCPMC9945342
OpenAlexW4288684136

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.