Evidence map›Paper›PMID 35909964›Full record

ArticleFrontiers in cellular and infection microbiology2022

The Innate Immune Protein Calprotectin Interacts With and Encases Biofilm Communities of

Jiwasmika Baishya, Jake A Everett, Walter J Chazin, Kendra P Rumbaugh, Catherine A Wakeman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Metal-independent effects of calprotectin on cocultures ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Calprotectin protectsmSystems · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Application of a quantitative framework to improve the accuracy of a bacterial infection model.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Biofilm control strategies in the light of biofilm-forming microorganisms.World journal of microbiology & biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jiwasmika BaishyaDepartment of Biological Sciences, Texas Tech University, Lubbock, TX, United States.
Jake A EverettDepartment of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
Walter J ChazinDepartment of Biochemistry, Vanderbilt University, Nashville, TN, United States.
Kendra P RumbaughDepartment of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
Catherine A WakemanDepartment of Biological Sciences, Texas Tech University, Lubbock, TX, United States.
Texas Tech University · USTexas Tech University Health Sciences Center · USVanderbilt University · US

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
Neisseria gonorrhoeae metal transporters that subvert nutritional immunityR01AI127793 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CYNTHIA N CORNELISSEN, Alison K Criss · 2017 to 2026
$6.8M
Protein Kinase C Signaling and Breast CancerR01CA118089 · NCI · WAYNE STATE UNIVERSITY · PI REDDY, KALADHAR B. · 2007 to 2011
$1.4M
Physiological profiling of Pseudomonas aeruginosa biofilm subpopulationsR15GM128072 · NIGMS · TEXAS TECH UNIVERSITY · PI WAKEMAN, CATHERINE ANN · 2018 to 2018
$432k
High-potency nitro antimicrobials for topical treatment of trichomoniasisR41AI118089 · NIAID · DESIGNMEDIX, INC. · PI ECKMANN, LARS, PEYTON, DAVID H · 2016 to 2016
$354k
NCI NIH HHS R01 CA118089NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI127793NIAID NIH HHS R41 AI118089NIGMS NIH HHS R15 GM128072
6 · The paper itself

Abstract

Calprotectin is a transition metal chelating protein of the innate immune response known to exert nutritional immunity upon microbial infection. It is abundantly released during inflammation and is therefore found at sites occupied by pathogens such as

Indexed as

BiofilmsImmunity, InnateLeukocyte L1 Antigen ComplexPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsExtracellular Polymeric Substance MatrixHumansPhagocytosisAnti-Bacterial AgentsLeukocyte L1 Antigen Complexbiofilm architecturecalprotectinextracellular polymeric substance (EPS)nutritional immunityPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID35909964
PMCPMC9325956
OpenAlexW4285085684

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.