Evidence map›Paper›PMID 35910529›Full record

ArticleJournal of diabetes research2022

Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study.

Daria Igudesman, Beth A Reboussin, Katherine J Souris, Catherine Pihoker, Lawrence Dolan, Jean M Lawrence, Sharon Saydah, Dana Dabelea, Santica Marcovina, Noémie Clouet-Foraison and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Daria IgudesmanDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0001-5209-4625
Beth A ReboussinDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.ORCID https://orcid.org/0000-0002-7318-9081
Katherine J SourisDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0003-3936-7339
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle Children's, Seattle, WA 98105, USA.ORCID https://orcid.org/0000-0001-9074-7770
Lawrence DolanDivision of Endocrinology, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID https://orcid.org/0000-0002-5359-0636
Jean M LawrenceDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena CA 91101, USA.ORCID https://orcid.org/0000-0002-2480-8480
Sharon SaydahDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID https://orcid.org/0000-0002-6350-5300
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0001-9514-8929
Santica MarcovinaDivision of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98195, USA.ORCID https://orcid.org/0000-0002-9118-8488
Noémie Clouet-ForaisonDivision of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98195, USA.ORCID https://orcid.org/0000-0002-3966-2453
Faisal S MalikDepartment of Pediatrics, University of Washington, Seattle Children's, Seattle, WA 98105, USA.ORCID https://orcid.org/0000-0002-2543-4214
Elizabeth J Mayer-DavisDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0003-3858-0517
University of North Carolina at Chapel Hill · USSeattle Children's Hospital · USUniversity of Washington · USCenters for Disease Control and Prevention · USColorado School of Public Health · USKaiser Permanente · USUniversity of Cincinnati Medical Center · USWake Forest University · US

Funding

NIDDK NIH HHS R01 DK127208
6 · The paper itself

Abstract

Objective: Hyperglycemia early in the course of type 1 diabetes (T1D) may increase the risk of cardiometabolic complications later in life. We tested the hypothesis that there were temporal trends in population-level glycemia and insulin pump use near T1D diagnosis among incident youth cohorts diagnosed between 2002 and 2016. Methods: Weighted and adjusted regression models were applied to data from the SEARCH for Diabetes in Youth study to analyze trends in hemoglobin A1c (HbA1c), suboptimal glycemia (HbA1c > 9% or not), and insulin pump use among youth with T1D within 30 months of diagnosis. We tested the interaction of year with race and ethnicity, sex, and insulin regimen to assess potential disparities. Results: Among the 3,956 youth with T1D, there was a small, clinically insignificant reduction in HbA1c between 2002 (7.9% ± 1.5) and 2016 (7.8% ± 2.4) (fully adjusted change by year (-0.013% [95% CI -0.026, -0.0008], Conclusions: There was not a clinically significant population-level improvement in glycemia across incident youth cohorts early in the course of T1D, despite severalfold increases in insulin pump use. Comprehensive clinical interventions to improve glycemia early in the T1D course and address disparities are urgently needed.

Indexed as

Diabetes Mellitus, Type 1AdolescentBlood GlucoseGlycated HemoglobinHumansInsulinInsulin Infusion SystemsBlood GlucoseGlycated HemoglobinInsulin

Identifiers

PMID35910529
PMCPMC9337956
OpenAlexW4286716877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.