ArticleFrontiers in public health2022
Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association between the history of abortion and gestational diabetes mellitus: A meta-analysis.Endocrine · 2023Pooled it
- The relationship between first trimester maternal diet and early pregnancy loss: a retrospective case-control study.BMC pregnancy and childbirth · 2026Article
- A multivariable risk prediction model for pregnancies of uncertain viability without a fetal pole: a prospective cohort study.Frontiers in medicine · 2026Article
- Optimizing the use of in vitro transcribed SGK1-mRNA as a therapeutic tool to treat female infertility.BMC research notes · 2025Article
- Article
- Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention.European journal of medical research · 2024Review
- Retinal Vascular Imaging Application in Women's Reproductive Health: Clinical Implications and Future Directions.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Association Between Age and the 28-Day All-Cause Mortality in Tuberculosis Complicated by Sepsis in ICU Patients: A Retrospective Cohort Study.Infection and drug resistance · 2024Article
- Factors associated with miscarriage in Nepal: Evidence from Nepal Demographic and Health Surveys, 2001-2016.PloS one · 2024Article
- Development and internal validation of a clinical prediction model for spontaneous abortion risk in early pregnancy.Clinics (Sao Paulo, Brazil) · 2024Article
- Investigating the unaccounted ones: insights on age-dependent reproductive loss in a viviparous fly.Frontiers in ecology and evolution · 2023Article
- Factors influencing clinical pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection in older women.African health sciences · 2023Article
- Factors Affecting the Outcomes of First in vitro Fertilization and Embryo Transfer: A Retrospective Investigation.International journal of women's health · 2023Article
- Pregnancy termination and determinant factors among women of reproductive age in Kenya, evidence from Kenyan Demographic and Health Survey 2022: Multilevel analysis.Women's health (London, England)Article
- The Strategies to Improve Healthcare Provider - Focus on Nurses.Gynecology and minimally invasive therapyReview
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Spontaneous abortion is one of the prevalent adverse reproductive outcomes, which seriously threatens maternal health around the world. Objective: The current study is aimed to evaluate the association between maternal age and risk for spontaneous abortion among pregnant women in China. Methods: This was a case-control study based on the China Birth Cohort, we compared 338 cases ending in spontaneous abortion with 1,352 controls resulting in normal live births. The main exposure indicator and outcome indicator were maternal age and spontaneous abortion, respectively. We used both a generalized additive model and a two-piece-wise linear model to determine the association. We further performed stratified analyses to test the robustness of the association between maternal age and spontaneous abortion in different subgroups. Results: We observed a J-shaped relationship between maternal age and spontaneous abortion risk, after adjusting for multiple covariates. Further, we found that the optimal threshold age was 29.68 years old. The adjusted odds ratio (95% confidence interval) of spontaneous abortion per 1 year increase in maternal age were 0.97 (0.90-1.06) on the left side of the turning point and 1.25 (1.28-1.31) on the right side. Additionally, none of the covariates studied modified the association between maternal age and spontaneous abortion ( Conclusions: Advanced maternal age (>30 years old) was significantly associated with increased prevalence of spontaneous abortion, supporting a J-shaped association between maternal age and spontaneous abortion.
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