Evidence map›Paper›PMID 35912118›Full record

ArticleFrontiers in cell and developmental biology2022

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in

Peiduo Liu, Kai Chang, Guillermo Requejo, Hua Bai

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Gene model for the ortholog ofmicroPublication biology · 2025
    Article
  7. Article
  8. The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Peiduo LiuDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, United States.
Kai ChangDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, United States.
Guillermo RequejoDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, United States.
Hua BaiDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, United States.
Iowa State University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Autonomous and Non-Autonomous Regulation of Cardiac AgingR01AG058741 · NIA · IOWA STATE UNIVERSITY · PI BAI, HUA · 2019 to 2023
$1.5M
NIA NIH HHS R01 AG058741NIH HHS P40 OD018537
6 · The paper itself

Abstract

High-fat diet (HFD)-induced obesity has become the major risk factor for the development of cardiovascular diseases, but the underlying mechanisms remain poorly understood. Here, we use

Indexed as

AktDrosophila cardiomyopathyDRP1mitochondrial dynamicsmitochondrial homeostasisrictorsemi-automatic optical heartbeat analysis (SOHA)

Identifiers

PMID35912118
PMCPMC9334792
OpenAlexW4285591584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.