Evidence map›Paper›PMID 35914636›Full record

ArticleVascular pharmacology2022

Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice.

Reem T Atawia, Jessica L Faulkner, Vinay Mehta, Andrew Austin, Coleton R Jordan, Simone Kennard, Eric J Belin de Chantemèle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vascular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Emerging Role of Leptin in Vascular and Placental Dysfunction in Preeclampsia.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Reem T AtawiaVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia.
Jessica L FaulknerVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia.
Vinay MehtaVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia.
Andrew AustinVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia.
Coleton R JordanVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia.
Simone KennardVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia.
Eric J Belin de ChantemèleVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, Georgia; Departments of Medicine (Cardiology), Medical College of Georgia, Augusta University, Augusta, GA, Georgia. Electronic address: ebelindechanteme@augusta.edu.
Augusta University · US

Funding

Mechanism of cardiovascular disease in premenopausal womenR01HL155265 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2022 to 2024
$1.6M
Leptin in HIV associated vascular diseasesR01HL147639 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2022 to 2023
$997k
NHLBI NIH HHS R00 HL146948NHLBI NIH HHS R01 HL130301NHLBI NIH HHS R01 HL147639NHLBI NIH HHS R01 HL155265
6 · The paper itself

Abstract

Leptin plays a crucial role in blood pressure (BP) regulation, notably in the context of obesity through central sympatho-mediated pressor effects. Leptin also relaxes arteries via endothelial (EC) leptin receptor (LepR

Indexed as

HypertensionReceptors, LeptinAdrenergic AgentsAnimalsEndotheliumLeptinMaleMiceNitric OxideObesityAdrenergic AgentsLeptinleptin receptor, mouseNitric OxideReceptors, LeptinAutonomic control of blood pressureHypertensionNitric oxideObesityResistance artery

Identifiers

PMID35914636
PMCPMC9561021
OpenAlexW4288808629

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.