Evidence map›Paper›PMID 35915156›Full record

ArticleNature medicine2022

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.

Catherine Tcheandjieu, Xiang Zhu, Austin T Hilliard, Shoa L Clarke, Valerio Napolioni, Shining Ma, Kyung Min Lee, Huaying Fang, Fei Chen, Yingchang Lu and 76 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 9 pooled it
59.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 9 syntheses or guidelines pooled it, 329 citations in OpenAlex.

  1. Pooled it
  2. Dissecting the Genetic Architecture of Intracranial Aneurysms.Circulation. Genomic and precision medicine · 2025
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  16. Assessing genetic risk factors for early-onset coronary artery disease in Iranians.Research and practice in thrombosis and haemostasis · 2026
    Article
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  19. Polygenic Prediction of Nongoal Response to Statin Therapy.Circulation. Genomic and precision medicine · 2026
    Article
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175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

86 authors at 20 institutions in 5 countries.

Catherine Tcheandjieu *VA Palo Alto Health Care System, Palo Alto, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0001-9559-4339
Xiang Zhu *VA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-1134-6413
Austin T Hilliard *VA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-1289-4377
Shoa L Clarke *VA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-6592-1172
Valerio NapolioniSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.ORCID http://orcid.org/0000-0002-4378-6838
Shining MaDepartment of Statistics, Stanford University, Stanford, CA, USA.
Kyung Min LeeVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
Huaying FangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Fei ChenDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Yingchang LuVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Noah L TsaoDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sridharan RaghavanMedicine Service, VA Eastern Colorado Health Care System, Aurora, CO, USA.
Satoshi KoyamaLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Bryan R GormanVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4239-4672
Marijana VujkovicCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4924-5714
Derek KlarinVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-4636-5780
Michael G LevinCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9937-9932
Nasa Sinnott-ArmstrongVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-4490-0601
Genevieve L WojcikDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7206-8088
Mary E PlomondonDepartment of Medicine, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Thomas M MaddoxHealthcare Innovation Lab, JC HealthCare/Washington University School of Medicine, St Louis, MO, USA.
Stephen W WaldoDepartment of Medicine, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Alexander G BickDepartment of Biomedical Informatics, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5824-9595
Saiju PyarajanVA Boston Healthcare System, Boston, MA, USA.
Jie HuangVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9036-4304
Rebecca SongVA Boston Healthcare System, Boston, MA, USA.
Yuk-Lam HoVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3305-3830
Steven BuyskeDepartment of Statistics, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-8539-5416
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7986-8560
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Ron DoCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3144-3627
Marie VerbanckCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kumardeep ChaudharyCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4117-6403
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8903-0366
Christy L AveryDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-1044-8162
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Christopher A HaimanDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Loïc Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, USA.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, USA.
Joshua C BisDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Hampton LeonardMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Botong ShenHealth Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Leslie A LangeDepartment of Medicine, Division of Biomedical Informatics and Personalized Medicine, Aurora, CO, USA.
Ayush GiriDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ozan DikilitasDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9906-8608
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6524-3471
Ian B StanawayDepartment of Medicine, Division of Nephrology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0783-0918
Gail P JarvikDepartment of Medicine, Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.
Adam S GordonCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Scott HebbringCenter for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, USA.
Bahram NamjouCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-4452-7878
Kenneth M KaufmanCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kaoru ItoLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Kazuyoshi IshigakiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0003-2881-0657
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Shefali S VermaDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1843-773X
Marylyn D RitchieDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1208-1720
Rachel L KemberCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8820-2659
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
Luca A LottaRegeneron Genetics Center, Tarrytown, NY, USA.
Regeneron Genetics Center
CARDIoGRAMplusC4D Consortium
Biobank Japan
Million Veteran Program
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth R HauserCooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC, USA.
Donald R MillerCenter for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA.ORCID http://orcid.org/0000-0002-7881-8801
Jennifer S LeeVA Palo Alto Health Care System, Palo Alto, CA, USA.
Danish SaleheenCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Peter D ReavenPhoenix VA Health Care System, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0001-8923-6690
Kelly ChoVA Boston Healthcare System, Boston, MA, USA.
J Michael GazianoVA Boston Healthcare System, Boston, MA, USA.
Pradeep NatarajanProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8402-7435
Jennifer E HuffmanVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-2491
Benjamin F VoightCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6205-9994
Daniel J RaderDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Kyong-Mi ChangCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6811-9364
Julie A LynchVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0108-2127
Scott M DamrauerDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8009-1632
Peter W F WilsonAtlanta VA Medical Center, Atlanta, GA, USA.
Hua TangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0177-8864
Yan V SunAtlanta VA Health Care System, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Philip S TsaoVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7274-9318
Christopher J O'DonnellVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2667-8624
Themistocles L AssimesVA Palo Alto Health Care System, Palo Alto, CA, USA. tassimes@stanford.edu.ORCID http://orcid.org/0000-0003-2349-0009
VA Palo Alto Health Care System · USBrigham and Women's Hospital · USBroad Institute · USPhiladelphia VA Medical Center · USRIKEN Center for Integrative Medical Sciences · JPIcahn School of Medicine at Mount Sinai · USStanford University · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of Washington · USVA Boston Healthcare System · USVanderbilt University Medical Center · USCincinnati Children's Hospital Medical Center · USFred Hutch Cancer Center · USMayo Clinic in Arizona · USNational Patient Safety Foundation · USRegeneron (United States) · USUniversity of Hawaiʻi at Mānoa · USUniversity of Southern California · USVA Salt Lake City Healthcare System · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Variation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Training Program in Cardiovascular Biology and MedicineT32HL007843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Sharlene M Day · 1996 to 2026
$11.0M
DNA Sequencing Support for the eMERGE NetworkU01HG008664 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2015 to 2019
$10.9M
BLRD VA I01 BX003340BLRD VA I01 BX003362BLRD VA I01 BX004821CSRD VA IK2 CX001780NCATS NIH HHS UL1 TR001881NCI NIH HHS T32 CA229110NCI NIH HHS U01 CA164973NHGRI NIH HHS R01 HG011432NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004599NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG004608NHGRI NIH HHS U01 HG004609NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008664NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008676NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701NHGRI NIH HHS U01 HG011172NHGRI NIH HHS U01 HG011719NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL139865NHLBI NIH HHS R01 HL142017NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R56 HL150186NHLBI NIH HHS T32 HL007843NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS HHSN271201100004CNIA NIH HHS K23 AG000989NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK101478NIDDK NIH HHS R01 DK114183NIDDK NIH HHS R01 DK134575NIDDK NIH HHS R56 DK101478NIDDK NIH HHS UM1 DK126194NIGMS NIH HHS R35 GM124836NIH HHS S10 OD028685WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including nine on the X chromosome, detect eight loci of genome-wide significance in Black and Hispanic individuals, and demonstrate that two common haplotypes at the 9p21 locus are responsible for risk stratification in all populations except those of African origin, in which these haplotypes are virtually absent. Moreover, in the largest GWAS for angiographically derived coronary atherosclerosis performed to date, we find 15 loci of genome-wide significance that robustly overlap with established loci for clinical CAD. Phenome-wide association analyses of novel loci and polygenic risk scores (PRSs) augment signals related to insulin resistance, extend pleiotropic associations of these loci to include smoking and family history, and precisely document the markedly reduced transferability of existing PRSs to Black individuals. Downstream integrative analyses reinforce the critical roles of vascular endothelial, fibroblast, and smooth muscle cells in CAD susceptibility, but also point to a shared biology between atherosclerosis and oncogenesis. This study highlights the value of diverse populations in further characterizing the genetic architecture of CAD.

Indexed as

Coronary Artery DiseaseGenome-Wide Association StudyGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideRisk Factors

Identifiers

PMID35915156
PMCPMC9419655
OpenAlexW4289261048

What Socratic holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.