Evidence map›Paper›PMID 35915930›Full record

ArticleEvolution; international journal of organic evolution2022

Luck, lottery, or legacy? The problem of confounding. A reply to Harden.

Graham Coop, Molly Przeworski

Abstract read
In one paragraph

Article in Evolution; international journal of organic evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Confounding fuels misinterpretation in human genetics.Proceedings. Biological sciences · 2025
    Article
  2. Confounding Fuels Misinterpretation in Human Genetics.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. All that glisters is not gold: Genetics and social science.The Behavioral and brain sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Graham CoopCenter for Population Biology and Department of Evolution and Ecology, University of California, Davis, CA, USA.ORCID 0000-0001-8431-0302
Molly PrzeworskiDepartment of Biological Sciences and Department of Systems Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-5369-9009

Funding

New methods for constructing and evaluating polygenic scoresR01HG011432 · NHGRI · STANFORD UNIVERSITY · PI PRITCHARD, JONATHAN K · 2020 to 2023
$3.3M
The impact of natural selection and population structure on human genomic variationR35GM136290 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Graham Coop · 2020 to 2026
$2.6M
Natural selection in recent human evolutionR01GM121372 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PRZEWORSKI, MOLLY F · 2017 to 2020
$1.6M
NHGRI NIH HHS R01 HG011432NIGMS NIH HHS NIH R35 GM136290NIGMS NIH HHS R01 GM121372NIGMS NIH HHS R35 GM136290
6 · The paper itself

Abstract

A reply to Harden's response to Coop and Przeworski (2022).

Identifiers

PMID35915930
PMCPMC9627830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.