Observational studyEuropean journal of neurology2022
Hospital-diagnosed sleep disorders and incident dementia: a nationwide observational cohort study.
Observational study in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.GeroScience · 2025Pooled it
- Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Risk factors and prediction model for sleep disorders in respiratory critically ill patients after intensive care unit transfer.American journal of translational research · 2026Article
- Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study.The journal of prevention of Alzheimer's disease · 2025Article
- Alzheimer's Disease in Illinois: Analyzing Disparities and Projected Trends.Geriatrics (Basel, Switzerland) · 2025Review
- Individual Sleep Problems Are Associated With an Accelerated Decline in Multiple Cognitive Functions in Older Adults.Journal of sleep research · 2025Article
- Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study.Scientific reports · 2025Article
- Review
- Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective.International journal of molecular sciences · 2024Review
- Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study.JMIR research protocols · 2024Article
- Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review.Frontiers in neuroscience · 2024Review
- Sleep disorders and increased risk of dementia.European journal of neurology · 2022Article
- Hospital-diagnosed sleep disorders and incident dementia: a nationwide observational cohort study.European journal of neurology · 2022Observational
- Sleep state of the elderly population in Korea: Nationwide cross-sectional population-based study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSeveral smaller, community-based studies have suggested a link between sleep disorders and dementia with a focus on sleep as a modifiable risk factor for dementia. Studies on neurodegenerative diseases are prone to reverse causation, and few studies have examined the association with long follow-up time. Our aim was to explore the possible association between sleep disorders and late-onset dementia in an entire population.
methodsIn a nationwide cohort with 40-year follow-up, associations between hospital-based sleep disorder diagnoses and late-onset dementia were assessed. Incidence rate ratios (IRR) were calculated using Poisson regression.
resultsThe cohort consisted of 1,491,276 people. Those with any sleep disorder had a 17% higher risk of dementia (IRR 1.17, 95% confidence interval [CI] 1.11-1.24) compared to people with no sleep disorder, adjusted for age, sex, calendar year, highest attained educational level at age 50, and somatic and psychiatric comorbidity. The risk of dementia was significantly increased 0-5 years after sleep disorder diagnosis (IRR 1.35, 95% CI 1.25-1.47), whilst the association after 5 years or more was non-significant (1.05, 95% CI 0.97-1.13).
conclusionsOur findings show an increased short-term risk of dementia following a hospital-based sleep disorder diagnosis, whilst weaker evidence of a long-term risk was found. This could potentially point towards sleep disorders as an early symptom of dementia. Further research is needed to distinguish sleep disorders as an early symptom of dementia, a risk factor, or both.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.