Evidence map›Paper›PMID 35918756›Full record

ArticleEpigenetics & chromatin2022

Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts.

John F Dou, Lauren Y M Middleton, Yihui Zhu, Kelly S Benke, Jason I Feinberg, Lisa A Croen, Irva Hertz-Picciotto, Craig J Newschaffer, Janine M LaSalle, Daniele Fallin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics & chromatin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

John F DouDepartment of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA.
Lauren Y M MiddletonDepartment of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA.
Yihui ZhuDepartment of Public Health Sciences and the M.I.N.D. Institute, School of Medicine, University of California, Davis, CA, USA.
Kelly S BenkeDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Jason I FeinbergDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Lisa A CroenKaiser Permanente Northern California, Oakland, CA, USA.
Irva Hertz-PicciottoDepartment of Public Health Sciences and the M.I.N.D. Institute, School of Medicine, University of California, Davis, CA, USA.
Craig J NewschafferCollege of Health and Human Development, Penn State University, State College, PA, USA.
Janine M LaSalleDepartment of Medical Microbiology and Immunology and the M.I.N.D. Institute, School of Medicine, University of California, Davis, CA, USA.
Daniele Fallin *Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Rebecca J Schmidt *Department of Public Health Sciences and the M.I.N.D. Institute, School of Medicine, University of California, Davis, CA, USA.
Kelly M Bakulski *Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, USA. bakulski@umich.edu.
University of California, Davis · USJohns Hopkins University · USUniversity of Michigan–Ann Arbor · USKaiser Permanente · USPennsylvania State University · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Early Autism Risk Longitudinal Investigation (EARLI) NetworkR01ES016443 · NIEHS · DREXEL UNIVERSITY · PI NEWSCHAFFER, CRAIG J · 2008 to 2013
$15.6M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic MarkersR01ES020392 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, OZONOFF, SALLY · 2011 to 2015
$9.0M
PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)R01ES029213 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Janine M LaSalle, Pamela J Lein · 2018 to 2026
$6.5M
DNA Methylation, Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort - Diversity SupplementR01AG067592 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2020 to 2025
$3.8M
Racial inequalities in health throughout adulthood: The cumulative impact of neighborhood chemical and non-chemical stressors on epigenomic pathwaysR01MD013299 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2018 to 2022
$3.7M
Environmental Influence on Infant Microbiome Development and ASD SymptomsR01ES028089 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, MILLS, DAVID ANDREW · 2016 to 2020
$3.6M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
Folic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESR24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany D. Chambers Butcher, Rebecca Jean Schmidt · 2017 to 2026
$2.3M
NIA NIH HHS R01 AG067592NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES016443NIEHS NIH HHS R01 ES020392NIEHS NIH HHS R01 ES025531NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R01 ES028089NIEHS NIH HHS R01 ES029213NIEHS NIH HHS R24 ES028533NIEHS NIH HHS R24 ES030893NIEHS NIH HHS U24 ES028533NIMHD NIH HHS R01 MD013299
6 · The paper itself

Abstract

backgroundPrenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, and vitamins A, B6, B12, and D, and usually they contain higher concentrations of folic acid and iron than regular multivitamins in the US Nutrient levels can impact epigenetic factors such as DNA methylation, but relationships between maternal prenatal vitamin use and DNA methylation have been relatively understudied. We examined use of prenatal vitamins in the first month of pregnancy in relation to cord blood and placenta DNA methylation in two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk Learning Early Signs (MARBLES) studies.

resultsIn placenta, prenatal vitamin intake was marginally associated with -0.52% (95% CI -1.04, 0.01) lower mean array-wide DNA methylation in EARLI, and associated with -0.60% (-1.08, -0.13) lower mean array-wide DNA methylation in MARBLES. There was little consistency in the associations between prenatal vitamin intake and single DNA methylation site effect estimates across cohorts and tissues, with only a few overlapping sites with correlated effect estimates. However, the single DNA methylation sites with p-value < 0.01 (EARLI cord n

conclusionsTogether, our findings suggest that prenatal vitamin intake in the first month of pregnancy may be related to lower placental global DNA methylation and related to DNA methylation in brain-related pathways in both placenta and cord blood.

Indexed as

DNA MethylationPlacentaFemaleFetal BloodFolic AcidHumansIronPregnancyProspective StudiesVitaminsFolic AcidIronVitaminsCord bloodDNA methylationEpidemiologyEpigeneticsPlacentaPregnancy cohortPrenatal vitamins

Identifiers

PMID35918756
PMCPMC9344645
OpenAlexW4289520779

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.