Evidence map›Paper›PMID 35920110›Full record

ReviewEuropean journal of heart failure2022

Atrial amyloidosis: mechanisms and clinical manifestations.

Giuseppe Vergaro, Alberto Aimo, Claudio Rapezzi, Vincenzo Castiglione, Iacopo Fabiani, Angela Pucci, Gabriele Buda, Claudio Passino, Josep Lupón, Antoni Bayes-Genis and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 82 citations in OpenAlex.

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  13. Intracardiac echocardiography for left ventricular diastolic function assessment during atrial fibrillation ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Giuseppe Vergaro *Interdisciplinary Center Health Science, Scuola Superiore Sant'Anna, Pisa, Italy.
Alberto Aimo *Interdisciplinary Center Health Science, Scuola Superiore Sant'Anna, Pisa, Italy.
Claudio RapezziCardiology Centre, University of Ferrara, Ferrara, Italy.
Vincenzo CastiglioneInterdisciplinary Center Health Science, Scuola Superiore Sant'Anna, Pisa, Italy.
Iacopo FabianiFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Angela PucciUniversity Hospital of Pisa, Pisa, Italy.
Gabriele BudaUniversity Hospital of Pisa, Pisa, Italy.
Claudio PassinoInterdisciplinary Center Health Science, Scuola Superiore Sant'Anna, Pisa, Italy.
Josep LupónHeart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Antoni Bayes-GenisHeart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Michele EmdinInterdisciplinary Center Health Science, Scuola Superiore Sant'Anna, Pisa, Italy.
Eugene BraunwaldCardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Fondazione Toscana Gabriele Monasterio · ITAzienda Ospedaliera Universitaria Pisana · ITScuola Superiore Sant'Anna · ITBrigham and Women's Hospital · USCentro de Investigación en Red en Enfermedades Cardiovasculares · ESHospital Universitari Germans Trias i Pujol · ESUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac amyloidosis (CA) is now recognized as an important cause of heart failure. Increased wall thickness and diastolic dysfunction of the left ventricle are the most easily detectable manifestations of CA, but amyloid accumulates in all cardiac structures. Involvement of the left and right atria may be due to the haemodynamic effects of ventricular diastolic dysfunction, the effects of amyloid infiltration into the atrial wall, and the cardiotoxic damage of atrial cardiomyocytes by amyloid precursors. Atrial amyloidosis is an early manifestation of CA, and is associated with an increased risk of atrial fibrillation and thromboembolic events. Furthermore, atrial amyloidosis can be found even in the absence of systemic disease and ventricular involvement. This condition is named isolated atrial amyloidosis and is due to a local overproduction of atrial natriuretic peptide. In this review we summarize the evidence on the mechanisms and clinical relevance of atrial amyloidosis.

Indexed as

Atrial FibrillationHeart FailureHumansAmyloidosisAtrial diseaseAtrial fibrillationHeartNatriuretic peptides

Identifiers

PMID35920110
PMCPMC10087817
OpenAlexW4289711551

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.