Evidence map›Paper›PMID 35922065›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Delta-like 4-Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10

Eun Hyeon Song, Ming Xu, Jie Yang, Yangming Xiao, Ann V Griffith, Na Xiong

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eun Hyeon SongThe Molecular, Cellular, and Integrative Biosciences Graduate Program, Pennsylvania State University, University Park, PA.ORCID 0000-0001-9524-2595
Ming XuDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, TX.
Jie YangThe Molecular, Cellular, and Integrative Biosciences Graduate Program, Pennsylvania State University, University Park, PA.
Yangming XiaoDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, TX.ORCID 0000-0003-0496-5291
Ann V GriffithDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, TX.ORCID 0000-0001-5345-0222
Na XiongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, TX; xiongn@uthscsa.edu.ORCID 0000-0003-4405-6818
Pennsylvania State University · USThe University of Texas Health Science Center at San Antonio · US

Funding

Preferential perinatal thymic programming of skin-homing innate lymphoid cells in early establishment of skin homeostasisU01AI131393 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XIONG, NA · 2017 to 2021
$1.9M
NIAID NIH HHS U01 AI131393
6 · The paper itself

Abstract

The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for development of innate lymphoid cells (ILCs). ILCs generated in thymi acquire unique homing properties that direct their localization into barrier tissues such as the skin and intestine, where they help local homeostasis. Mechanisms underlying the developmental programming of unique tissue-homing properties of ILCs are poorly understood. We report in this article that thymic stroma-derived Notch signaling is differentially involved in thymic generation of a population of NK1.1

Indexed as

Immunity, InnateLymphocytesAnimalsCell DifferentiationLigandsMiceMice, KnockoutLigands

Identifiers

PMID35922065
PMCPMC9492633
OpenAlexW4290100650

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.