Evidence map›Paper›PMID 35922892›Full record

ArticleJournal of cutaneous pathology2023

Eosinophil-rich linear IgA bullous dermatosis induced by mRNA COVID-19 booster vaccine.

William J Nahm, Michelle Juarez, Julie Wu, Randie H Kim

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of cutaneous pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. Linear IgA bullous dermatosis after COVID-19 vaccination.International journal of dermatology · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

William J NahmThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-2335-8780
Michelle JuarezThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-5791-4984
Julie WuThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0001-5841-0414
Randie H KimThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0003-0365-5961
New York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of eosinophil-rich linear IgA bullous disease (LABD) following the administration of a messenger RNA COVID-19 booster vaccine. A 66-year-old man presented to the emergency department with a 3-week history of a pruritic blistering rash characterized by fluid-filled bullae and multiple annular and polycyclic plaques. He was initially diagnosed with bullous pemphigoid based on a biopsy showing a subepidermal blister with numerous eosinophils. However, direct immunofluorescence studies showed linear IgA and IgM deposition along the basement membrane zone with no immunoreactivity for C3 or IgG. Additionally, indirect immunofluorescence was positive for IgA basement membrane zone antibody. The patient was subsequently diagnosed with LABD and initiated on dapsone therapy with resolution of his lesions at 3-month follow-up. This case illustrates the growing number of autoimmune blistering adverse cutaneous reactions from vaccination. Dermatopathologists should be aware that features of autoimmune blistering diseases can overlap and may not be distinguishable based on these histopathological findings alone. Confirmation with direct immunofluorescence and/or serological studies may be necessary for accurate diagnosis.

Indexed as

Autoimmune DiseasesCOVID-19Linear IgA Bullous DermatosisPrurigoVaccinesAgedBlisterEosinophilsHumansImmunoglobulin AMaleImmunoglobulin AVaccinesCOVID-19direct immunofluorescencelinear IgA bullous dermatosisModerna boostervaccine

Identifiers

PMID35922892
PMCPMC9538274
OpenAlexW4289711703

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.