Evidence map›Paper›PMID 35923707›Full record

ArticleFrontiers in genetics2022

Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes.

Carina M Mathey, Carlo Maj, Annika B Scheer, Julia Fazaal, Bettina Wedi, Dorothea Wieczorek, Philipp M Amann, Harald Löffler, Lukas Koch, Clemens Schöffl and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Bradykinin-Mediated Angioedema Induced by Drugs.Journal of clinical medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Prediction and prevention of ACE-inhibitor-induced angioedema-an unmet clinical need in management of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 15 institutions in 4 countries.

Carina M MatheyInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Carlo MajInstitute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany.
Annika B ScheerInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Julia FazaalInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Bettina WediDepartment of Dermatology and Allergy, Comprehensive Allergy Center, Hannover Medical School, Hannover, Germany.
Dorothea WieczorekDepartment of Dermatology and Allergy, Comprehensive Allergy Center, Hannover Medical School, Hannover, Germany.
Philipp M AmannDepartment of Dermatology, SLK Hospital Heilbronn, Heilbronn, Germany.
Harald LöfflerDepartment of Dermatology, SLK Hospital Heilbronn, Heilbronn, Germany.
Lukas KochDepartment of Dermatology and Venereology, Medical University Graz, Graz, Austria.
Clemens SchöfflDepartment of Dermatology and Venereology, Medical University Graz, Graz, Austria.
Heinrich DickelDepartment of Dermatology, Venereology and Allergology, St. Josef Hospital, University Medical Center, Ruhr University Bochum, Bochum, Germany.
Nomun GanjuurDepartment of Dermatology, Venereology and Allergology, St. Josef Hospital, University Medical Center, Ruhr University Bochum, Bochum, Germany.
Thorsten HornungDepartment of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany.
Susann ForkelDepartment of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
Jens GreveDepartment of Otorhinolaryngology-Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.
Gerda WurptsDepartment of Dermatology and Allergy, Aachen Comprehensive Allergy Center, University Hospital RWTH Aachen, Aachen, Germany.
Pär HallbergDepartment of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Anette BygumDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Christian Von BuchwaldDepartment of Otorhinolaryngology-Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Malgorzata KarawajczykDepartment of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Michael SteffensResearch Division, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
Julia StinglInstitute for Clinical Pharmacology, RWTH Aachen University, Aachen, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Elisabeth MangoldInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Kerstin U LudwigInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Eva R RasmussenDepartment of Otorhinolaryngology-Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Mia WadeliusDepartment of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Bernhardt SachsDepartment of Dermatology and Allergy, Aachen Comprehensive Allergy Center, University Hospital RWTH Aachen, Aachen, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
University Hospital Bonn · DEUniversity of Bonn · DERWTH Aachen University · DEMedical University of Graz · ATMedizinische Hochschule Hannover · DEScience for Life Laboratory · SESLK-Kliniken Heilbronn · DEUniversity of Copenhagen · DKFederal Institute for Drugs and Medical Devices · DEOdense University Hospital · DKPhilipps University of Marburg · DERuhr University Bochum · DESt. Josef-Hospital · DEUniversitätsmedizin Göttingen · DEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angioedema is a relatively rare but potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). As with hereditary forms of angioedema (HAE), this adverse reaction is mediated by bradykinin. Research suggests that ACEi/ARB-induced angioedema has a multifactorial etiology. In addition, recent case reports suggest that some ACEi/ARB-induced angioedema patients may carry pathogenic HAE variants. The aim of the present study was to investigate the possible association between ACEi/ARB-induced angioedema and HAE genes

Indexed as

angioedemaangiotensin-converting enzyme inhibitorangiotensin receptor blockergeneticshereditary angioedemasequencing

Identifiers

PMID35923707
PMCPMC9339951
OpenAlexW4285727420

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.