ArticleBMC medical imaging2022
Differences in brain activity between normal and diabetic rats under isoflurane anesthesia: a resting-state functional MRI study.
Article in BMC medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A New Nanotechnology for Imaging the Juxta-Articular Intraosseous Vasculature-Canal Complex and Related Clinical Pilot Studies.Orthopaedic surgery · 2025Article
- Functional MRI Analysis of Brain Activity in Rats With Diabetic Bladder Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study.Inflammopharmacology · 2024Article
- Sex differences in functional and structural alterations of hippocampus region in chronic pain: a DTI and resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Controlled release of Clenbuterol from a hydroxyapatite carrier for the treatment of Alzheimer's Disease.Biomaterials research · 2023Article
- RU-Net: skull stripping in rat brain MR images after ischemic stroke with rat U-Net.BMC medical imaging · 2023Article
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7 authors.
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Abstract
backgroundAltered neural activity based on the fractional amplitude of low-frequency fluctuations (fALFF) has been reported in patients with diabetes. However, whether fALFF can differentiate healthy controls from diabetic animals under anesthesia remains unclear. The study aimed to elucidate the changes in fALFF in a rat model of diabetes under isoflurane anesthesia.
methodsThe first group of rats (n = 5) received a single intraperitoneal injection of 70 mg/kg streptozotocin (STZ) to cause the development of diabetes. The second group of rats (n = 7) received a single intraperitoneal injection of the same volume of solvent. Resting-state functional magnetic resonance imaging was used to assess brain activity at 4 weeks after STZ or solvent administration.
resultsCompared to the healthy control animals, rats with diabetes showed significantly decreased fALFF in various brain regions, including the cingulate cortex, somatosensory cortex, insula, and striatum (all P < 0.05). The decreased fALFF suggests the aberrant neural activities in the diabetic rats. No regions were detected in which the control group had a lower fALFF than that in the diabetes group.
conclusionsThe results of this study demonstrated that the fALFF could be used to differentiate healthy controls from diabetic animals, providing meaningful information regarding the neurological pathophysiology of diabetes in animal models.
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