Evidence map›Paper›PMID 35928948›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Force-Bioreactor for Assessing Pharmacological Therapies for Mechanobiological Targets.

Austin J Scholp, Jordan Jensen, Sathivel Chinnathambi, Keerthi Atluri, Alyssa Mendenhall, Timothy Fowler, Aliasger K Salem, James A Martin, Edward A Sander

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Austin J ScholpRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA, United States.
Jordan JensenRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA, United States.
Sathivel ChinnathambiRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA, United States.
Keerthi AtluriDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States.
Alyssa MendenhallRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA, United States.
Timothy FowlerDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Aliasger K SalemDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States.
James A MartinDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Edward A SanderRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA, United States.
University of Iowa · USTranslational Therapeutics (United States) · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Preventing Recurrent Capsular Contracture in Traumatic Elbow InjuriesR21AR075137 · NIAMS · UNIVERSITY OF IOWA · PI SANDER, EDWARD A · 2020 to 2021
$357k
NIAMS NIH HHS R21 AR075137NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Tissue fibrosis is a major health issue that impacts millions of people and is costly to treat. However, few effective anti-fibrotic treatments are available. Due to their central role in fibrotic tissue deposition, fibroblasts and myofibroblasts are the target of many therapeutic strategies centered primarily on either inducing apoptosis or blocking mechanical or biochemical stimulation that leads to excessive collagen production. Part of the development of these drugs for clinical use involves

Indexed as

blebbistatincollagenfibrinfibroblastsfibrosis

Identifiers

PMID35928948
PMCPMC9343955
OpenAlexW4285797167

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.