Evidence map›Paper›PMID 35929063›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2022

Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis.

Jan Spaas, Richie P Goulding, Charly Keytsman, Lena Fonteyn, Jack van Horssen, Richard T Jaspers, Bert O Eijnde, Rob C I Wüst

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05954195 (Effect of High Intensity Interval Training in Patients With Multiple Sclerosis), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05954195 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of High Intensity Interval Training in Patients With Multiple Sclerosis: Systematic Review

TypeinterventionalSponsorCairo UniversityRan2023 to 2023Enrolled86ConditionsMultiple SclerosisArmshigh intensity interval training
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Mitochondria transcription and cancer.Cell death discovery · 2024
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jan SpaasUniversity MS Center (UMSC) Hasselt - Pelt, Hasselt, Belgium.ORCID 0000-0002-4953-2505
Richie P GouldingLaboratory for Myology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Charly KeytsmanUniversity MS Center (UMSC) Hasselt - Pelt, Hasselt, Belgium.
Lena FonteynUniversity MS Center (UMSC) Hasselt - Pelt, Hasselt, Belgium.
Jack van HorssenUniversity MS Center (UMSC) Hasselt - Pelt, Hasselt, Belgium.
Richard T JaspersLaboratory for Myology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Bert O EijndeUniversity MS Center (UMSC) Hasselt - Pelt, Hasselt, Belgium.
Rob C I WüstLaboratory for Myology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Hasselt University · BEVrije Universiteit Amsterdam · NLAmsterdam Neuroscience · NLGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system and peripheral muscle in MS-induced exercise intolerance before and after exercise training.

methodsTwenty-three patients with MS (13 women) and 20 age-matched and sex-matched healthy controls (13 women) performed a cardiopulmonary exercise test. Muscle fibre type composition, size, succinate dehydrogenase (SDH) activity, capillarity, and gene expression and proteins related to mitochondrial density were determined in vastus lateralis muscle biopsies. Nine MS patients (five women) were re-examined following a 12 week exercise training programme consisting of high-intensity cycling interval and resistance training.

resultsPatients with MS had lower maximal oxygen uptake compared with healthy controls (V̇O

conclusionsSkeletal muscle oxidative phenotype (mitochondrial complex I and II content, SDH activity) is lower in patients with MS, contributing to reduced exercise tolerance. However, skeletal muscle mitochondria appeared resistant to the beneficial effects of exercise training, suggesting that other physiological systems, at least in part, drive the improvements in exercise capacity following exercise training in MS.

Indexed as

Exercise ToleranceMultiple SclerosisExerciseFemaleHumansMaleMuscle, SkeletalOxidative StressOxygenOxygen ConsumptionPhenotypePPAR gammaQuality of LifeSuccinate DehydrogenaseOxygenPPAR gammaSuccinate DehydrogenaseExercise capacityExercise therapyMitochondriaMultiple sclerosisOxidative metabolismSkeletal muscle

Identifiers

PMID35929063
PMCPMC9530506
OpenAlexW4289943512

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.