Evidence map›Paper›PMID 35929605›Full record

ArticleJournal of cancer biology2021

Changing the landscape of non-small cell lung cancer disparities.

Joab O Odera, Muthana Al Abo, Steven R Patierno, Jeffrey M Clarke, Jennifer A Freedman

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joab O OderaDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.
Muthana Al AboDuke Cancer Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
Steven R PatiernoDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.
Jeffrey M ClarkeDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.
Jennifer A FreedmanDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.
Duke University · US

Funding

Project 2: Racial differences in host immune response and gastric carcinogenesis: Translating underlying biology to promote gastric cancer interceptionP20CA251657 · NCI · DUKE UNIVERSITY · PI POLLAK, KATHRYN I · 2020 to 2022
$3.2M
Race-related alternative splicing: novel targets in prostate cancerR01CA220314 · NCI · DUKE UNIVERSITY · PI PATIERNO, STEVEN R · 2017 to 2021
$1.8M
Pilot Project 2P20CA202925 · NCI · DUKE UNIVERSITY · PI PATIERNO, STEVEN R, WILLIAMS, KEVIN PETER · 2016 to 2019
$1.3M
Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancerR01CA253312 · NCI · DUKE UNIVERSITY · PI CLARKE, JEFFREY MELSON, FREEDMAN, JENNIFER ANN · 2020 to 2020
$377k
NCI NIH HHS P20 CA202925NCI NIH HHS P20 CA251657NCI NIH HHS R01 CA220314NCI NIH HHS R01 CA253312
6 · The paper itself

Abstract

In the United States, lung and bronchus cancers are the second most common types of cancer and are responsible for the largest number of deaths from cancer, with African Americans suffering disproportionately from lung and bronchus cancers. This disparity likely results from a complex interplay among social, psycho-social, lifestyle, environmental, health system, and biological determinants of health. Toward improving outcomes for lung cancer patients of all races and ethnicities and mitigating lung cancer disparities, in this commentary, we bring forward biological factors that contribute to lung cancer disparities, efforts to identify, functionally characterize, and modulate novel ancestry-related RNA splicing-related targets in lung cancer for precision intervention, and translational and clinical research needs to improve outcomes for lung cancer patients of all races and ethnicities and mitigate lung cancer disparities.

Indexed as

AncestryBiomarkersDisparitiesImmunotherapiesLung adenocarcinomaLung cancerLung squamous cell carcinomaNon-small cell lung cancerRNA splicingTherapeutics

Identifiers

PMID35929605
PMCPMC9347607
OpenAlexW4250380254

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.