Evidence map›Paper›PMID 35930075›Full record

SynthesisActa diabetologica2022

There is no dose-response relationship between the amount of exercise and improvement in HbA1c in interventions over 12 weeks in patients with type 2 diabetes: a meta-analysis and meta-regression.

Elizabeth Wrench, Kate Rattley, Joel E Lambert, Rebecca Killick, Lawrence D Hayes, Robert M Lauder, Christopher J Gaffney

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
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  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth WrenchLancaster Medical School, Health Innovation One, Lancaster University, Sir John Fisher Drive, Lancaster, LA1 4AT, UK. l.wrench@lancaster.ac.uk.ORCID http://orcid.org/0000-0001-7139-5079
Kate RattleyLancaster Medical School, Health Innovation One, Lancaster University, Sir John Fisher Drive, Lancaster, LA1 4AT, UK.
Joel E LambertLancaster Medical School, Health Innovation One, Lancaster University, Sir John Fisher Drive, Lancaster, LA1 4AT, UK.
Rebecca KillickMathematics and Statistics, Lancaster University, Lancaster, LA1 4YG, UK.
Lawrence D HayesInstitute of Clinical Exercise and Health Science, School of Health and Life Sciences, University of West of Scotland, Glasgow, G72 0LH, UK.
Robert M LauderLancaster Medical School, Health Innovation One, Lancaster University, Sir John Fisher Drive, Lancaster, LA1 4AT, UK.
Christopher J GaffneyLancaster Medical School, Health Innovation One, Lancaster University, Sir John Fisher Drive, Lancaster, LA1 4AT, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAerobic exercise is well recognised as an effective treatment for people with type 2 diabetes but the optimal amount of aerobic exercise to improve glycaemic control remains to be determined. Thus, the aim of this meta-analysis and meta-regression was to assess the impact of volume and intensity of aerobic exercise on glycaemic control.

methodsMedline, Cochrane, Embase, and Web of Science databases were searched up until 15 December 2020 for the terms "aerobic exercise AND glycaemic control", "type 2 diabetes AND exercise", and "exercise AND glycaemic control AND Type 2 diabetes AND randomised control trial". We included (i) randomised control trials of ≥ 12 weeks, (ii) trials where participants had type 2 diabetes and were aged 18 or over, and (iii) the trial reported HbA1c concentrations pre- and post-intervention. Two reviewers selected studies and extracted data. Data are reported as standardised mean difference (SMD) and publication bias was assessed using funnel plots.

resultsA total of 5364 original titles were identified. Sixteen studies were included in the meta-analysis. Aerobic exercise reduced HbA1c versus control (SMD = 0.56 (95% CI 0.3-0.82), p < 0.001). There were also significant reductions in BMI (SMD = 0.76 (95% CI 0.25-1.27), p < 0.05). There was no dose-response relationship between improvement in HbA1c and the intensity and volume of the intervention (p > 0.05).

conclusionsTwelve-week or longer aerobic exercise programmes improve glycaemic control and BMI in adults with type 2 diabetes. Longer or more intense interventions appear to confer no additional benefit on HbA1c.

Indexed as

Diabetes Mellitus, Type 2AdultExerciseGlycated HemoglobinHumansGlycated HemoglobinAerobic exerciseGlycaemic controlHbA1cType 2 diabetes

Identifiers

PMID35930075
PMCPMC9519659

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.