Evidence map›Paper›PMID 35930733›Full record

ArticleACS sensors2022

Rapid Detection of Urinary Tract Infection in 10 min by Tracking Multiple Phenotypic Features in a 30 s Large-Volume Scattering Video of Urine Microscopy.

Fenni Zhang, Manni Mo, Jiapei Jiang, Xinyu Zhou, Michelle McBride, Yunze Yang, Kenta S Reilly, Thomas E Grys, Shelley E Haydel, Nongjian Tao and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Label-free single-particle imaging approach for ultra-rapid detection of pathogenic bacteria in clinical samples.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Fenni ZhangBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0000-0002-4369-8563
Manni MoBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0000-0002-0253-0406
Jiapei JiangBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.
Xinyu ZhouBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0000-0003-1399-828X
Michelle McBrideBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.
Yunze YangBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.
Kenta S ReillyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, Arizona 85054, United States.
Thomas E GrysDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, Arizona 85054, United States.
Shelley E HaydelBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0000-0001-5542-5469
Nongjian TaoBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.
Shaopeng WangBiodesign Center for Bioelectronics and Biosensors, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0000-0002-2680-0503
BioElectronics (United States) · USTempe Union High School District · USMayo Clinic Hospital · US

Funding

Point-of-care antimicrobial susceptibility testing based on simultaneous tracking of multi-phenotypic features of single bacterial cellsR01AI138993 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, SHAOPENG · 2018 to 2022
$5.5M
NIAID NIH HHS R01 AI138993
6 · The paper itself

Abstract

Rapid point-of-care (POC) diagnosis of bacterial infection diseases provides clinical benefits of prompt initiation of antimicrobial therapy and reduction of the overuse/misuse of unnecessary antibiotics for nonbacterial infections. We present here a POC compatible method for rapid bacterial infection detection in 10 min. We use a large-volume solution scattering imaging (LVSi) system with low magnifications (1-2×) to visualize bacteria in clinical samples, thus eliminating the need for culture-based isolation and enrichment. We tracked multiple intrinsic phenotypic features of individual cells in a short video. By clustering these features with a simple machine learning algorithm, we can differentiate

Indexed as

Bacterial InfectionsUrinary Tract InfectionsAnti-Bacterial AgentsBacteriaEscherichia coliHumansMicroscopyUrinalysisAnti-Bacterial Agentsbacteria detectionmachine learningmultiple phenotypic featuressolution scattering imagingUTI screening

Identifiers

PMID35930733
PMCPMC9465977
OpenAlexW4293382194

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.