ArticleBiological psychiatry2022
Associations Between Sleep Health and Amygdala Reactivity to Negative Facial Expressions in the UK Biobank Cohort.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Convergent abnormality in the subgenual anterior cingulate cortex in insomnia disorder: A revisited neuroimaging meta-analysis of 39 studies.Sleep medicine reviews · 2023Pooled it
- Data-driven derivation of a multidimensional sleep health framework in adolescents.Sleep health · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Sleep Health and White Matter Integrity in the UK Biobank.Journal of sleep research · 2025Article
- The Future of Insomnia Research-There's Still Work to Be Done.Journal of sleep research · 2025Review
- Association of chronotype and depression symptoms in Chinese infertile population undergoing assisted reproductive technology.Frontiers in psychology · 2025Article
- Frontoparietal Response to Working Memory Load Mediates the Association between Sleep Duration and Cognitive Function in Children.Brain sciences · 2024Article
- The new science of sleep: From cells to large-scale societies.PLoS biology · 2024Article
- Increased functional connectivity within the salience network in patients with insomnia.Sleep & breathing = Schlaf & Atmung · 2024Article
- A precision neuroscience approach to estimating reliability of neural responses during emotion processing: Implications for task-fMRI.NeuroImage · 2024Article
- Covariance patterns between sleep health domains and distributed intrinsic functional connectivity.Nature communications · 2023Article
- Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia.Frontiers in human neuroscience · 2023Article
- Associations between sleep health and grey matter volume in the UK Biobank cohort (Brain communications · 2023Article
- Sleep health as a predictor of the course of depressed mood and loss of interest in individuals with depression.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundSleep health (SH) is considered a key determinant of human physiological and psychological well-being. In line with this, previous studies have found that poor sleep is associated with various psychiatric disorders, in particular, with anxiety and depression. Although little is known about the neural mechanisms underlying these associations, recent findings suggest that essential dimensions of SH are associated with altered amygdala reactivity (AR); however, evidence to date is inconsistent and reliant on small sample sizes.
methodsTo address this problem, the current preregistered study investigated associations between SH and AR to negative facial expressions in the UK Biobank cohort (25,758 participants). Drawing on a large sample size and consistent data acquisition, 5 dimensions of SH (insomnia symptoms, sleep duration, daytime sleepiness, chronotype, and sleep medication) were examined.
resultsExploratory analyses revealed that short sleep duration was associated with decreased AR. The remaining SH dimensions and a composite measure of all SH dimensions were not associated with AR.
conclusionsTo our knowledge, this is the largest study to test associations between SH and AR. Habitual short sleep duration may be associated with decreased AR, possibly indicating compensation for impaired prefrontal processes and hampered emotion regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.