Evidence map›Paper›PMID 35933954›Full record

ArticleJournal of biomechanics2022

Biochemical and biomechanical characterization of the cervical, thoracic, and lumbar facet joint cartilage in the Yucatan minipig.

Rachel C Nordberg, Andrew N Kim, Justin M Hight, Rithika S Meka, Benjamin D Elder, Jerry C Hu, Kyriacos A Athanasiou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rachel C NordbergDepartment of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA 92617, USA.
Andrew N KimDepartment of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA 92617, USA.
Justin M HightDepartment of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA 92617, USA.
Rithika S MekaDepartment of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA 92617, USA.
Benjamin D ElderDepartment of Neurosurgery, Orthopedics, and Biomedical Engineering, Mayo Clinic School of Medicine, 200 1st St. SW, Rochester, MN 55905, USA.
Jerry C HuDepartment of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA 92617, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA 92617, USA. Electronic address: athens@uci.edu.
University of California, Irvine · USMayo Clinic · US

Funding

NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
Self-assembling process in tissue engineering of articular cartilageR01AR067821 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2015 to 2019
$1.9M
Toward tissue engineering of facet cartilageR01AR078389 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2021 to 2025
$1.7M
NCATS NIH HHS TL1 TR001415NIAMS NIH HHS R01 AR067821NIAMS NIH HHS R01 AR078389
6 · The paper itself

Abstract

Facet joint arthrosis causes pain in approximately 7 % of the U.S. population, but current treatments are palliative. The objective of this study was to elucidate structure-function relationships and aid in the development of future treatments for the facet joint. This study characterized the articular surfaces of cervical, thoracic, and lumbar facet cartilage from skeletally mature (18-24 mo) Yucatan minipigs. The minipig was selected as the animal model because it is recognized by the U.S. Food and Drug Administration (FDA) and the American Society for Testing and Materials (ASTM) as a translationally relevant model for spine-related indications. It was found that the thoracic facets had a ∼2 times higher aspect ratio than lumbar and cervical facets. Lumbar facets had 6.9-9.6 times higher % depth than the cervical and thoracic facets. Aggregate modulus values ranged from 135 to 262 kPa, much lower than reported aggregate modulus in the human knee (reported to be 530-701 kPa). The tensile Young's modulus values ranged from 6.7 to 20.3 MPa, with the lumbar superior facet being 304 % and 286 % higher than the cervical inferior and thoracic superior facets, respectively. Moreover, 3D reconstructions of entire vertebral segments were generated. The results of this study imply that structure-function relationships in the facet cartilage are different from other joint cartilages because biochemical properties are analogous to other articular cartilage sources whereas mechanical properties are not. By providing functional properties and a 3D database of minipig facet geometries, this work may supply design criteria for future facet tissue engineering efforts.

Indexed as

Cartilage, ArticularZygapophyseal JointAnimalsBiomechanical PhenomenaElastic ModulusHumansLumbar VertebraeSpineSwineSwine, MiniatureBiomechanicsCartilageCharacterizationFacet jointMinipigStructure-function relationshipsZygapophyseal joint

Identifiers

PMID35933954
PMCPMC9910803
OpenAlexW4288886117

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.