Evidence map›Paper›PMID 35934270›Full record

ArticleThe Journal of nutritional biochemistry2022

1α,25-dihydroxyvitamin D reduction of MCF10A-ras cell viability in extracellular matrix detached conditions is dependent on regulation of pyruvate carboxylase.

Madeline P Sheeley, Violet A Kiesel, Chaylen Andolino, Nadia A Lanman, Shawn S Donkin, Stephen D Hursting, Michael K Wendt, Dorothy Teegarden

Open access · greenAbstract read
In one paragraph

Article in The Journal of nutritional biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Madeline P SheeleyDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Violet A KieselDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Chaylen AndolinoDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Nadia A LanmanPurdue University Center for Cancer Research, West Lafayette, IN, USA; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
Shawn S DonkinDepartment of Animal Science, Purdue University, West Lafayette, IN, USA.
Stephen D HurstingDepartment of Nutrition, University of North Carolina at Chapel Hill,Chapel Hill, NC, USA.
Michael K WendtPurdue University Center for Cancer Research, West Lafayette, IN, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Dorothy TeegardenDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA; Purdue University Center for Cancer Research, West Lafayette, IN, USA. Electronic address: teegarden@purdue.edu.
Purdue University West Lafayette · USUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer ChemoresistanceR35CA197627 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HURSTING, STEPHEN D · 2015 to 2021
$6.0M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
Obesity, Metabolism and Breast Cancer MetastasisR01CA232589 · NCI · PURDUE UNIVERSITY · PI HURSTING, STEPHEN D, TEEGARDEN, DOROTHY · 2019 to 2023
$2.6M
Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progressionR01CA271597 · NCI · PURDUE UNIVERSITY · PI Stephen D Hursting, Dorothy Teegarden · 2023 to 2026
$2.5M
NCATS NIH HHS UL1 TR000006NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA232589NCI NIH HHS R01 CA271597NCI NIH HHS R35 CA197627
6 · The paper itself

Abstract

An emerging hallmark of cancer is cellular metabolic reprogramming to adapt to varying cellular environments. Throughout the process of metastasis cancer cells gain anchorage independence which confers survival characteristics when detached from the extracellular matrix (ECM). Previous work demonstrates that the bioactive metabolite of vitamin D, 1α,25-dihydroxyvitamin D (1,25[OH]

Indexed as

MalatesPyruvate CarboxylaseAspartic AcidCell SurvivalDoxycyclineExtracellular MatrixGlucoseGlutamic AcidGlutamineRNA, MessengerRNA, Small InterferingVitamin D1,25-dihydroxyvitamin DAspartic AcidDoxycyclineGlucoseGlutamic AcidGlutamineMalatesmalic acidPyruvate CarboxylaseRNA, MessengerRNA, Small InterferingVitamin D1,25-dihydroxyvitamin Dbreast cancerenergy metabolismglucose metabolismglutamine metabolismpyruvate carboxylase

Identifiers

PMID35934270
PMCPMC9719603
OpenAlexW4289755353

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.