Evidence map›Paper›PMID 35935936›Full record

SynthesisFrontiers in immunology2022

Efficacy and Safety of Curcumin and

Liuting Zeng, Tiejun Yang, Kailin Yang, Ganpeng Yu, Jun Li, Wang Xiang, Hua Chen

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06359665 (A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis), which is not on this map. Cited by 94 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 7 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06359665 phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis

TypeinterventionalSponsorBrent DeGeorgeRan2025 to 2026Enrolled100ConditionsArthritis of Carpometacarpal Joint of Left Thumb, Arthritis of Carpometacarpal Joint of Right ThumbArmsCurcumin, Placebo
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 7 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Liuting ZengDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Tiejun YangDepartment of Orthopedics, People's Hospital of Ningxiang City, Ningxiang City, China.
Kailin YangKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha City, China.
Ganpeng YuDepartment of Orthopedics, People's Hospital of Ningxiang City, Ningxiang City, China.
Jun LiDepartment of Orthopedics, People's Hospital of Ningxiang City, Ningxiang City, China.
Wang XiangDepartment of Rheumatology, The First People's Hospital Changde City, Changde City, China.
Hua ChenDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Jiangxi Pingxiang People's Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHunan University of Traditional Chinese Medicine · CNPeking Union Medical College Hospital · CNThe First People's Hospital of Changde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Modern pharmacological research found that the chemical components of Methods: Pubmed, Cochran Library, CNKI, and other databases were searched to collect the randomized controlled trials (RCTs). Then, the risk of bias of RCTs were assessed and data of RCTs were extracted. Finally, RevMan 5.3 was utilized for meta-analysis. Results: Twenty-nine (29) RCTs involving 2396 participants and 5 types of arthritis were included. The arthritis included Ankylosing Spondylitis (AS), Rheumatoid Arthritis (RA), Osteoarthritis (OA), Juvenile idiopathic arthritis (JIA) and gout/hyperuricemia. Curcumin and Curcuma longa Extract were administered in doses ranging from 120 mg to 1500 mg for a duration of 4-36 weeks. In general, Curcumin and Curcuma longa Extract showed safety in all studies and improved the severity of inflammation and pain levels in these arthritis patients. However, more RCTs are needed in the future to elucidate the effect of Curcumin and Curcuma longa Extract supplementation in patients with arthritis, including RA, OA, AS and JIA. Conclusion: Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.

Indexed as

Arthritis, RheumatoidCurcuminOsteoarthritisSpondylitis, AnkylosingCurcumaHumansInflammationPlant ExtractsRandomized Controlled Trials as TopicCurcuminPlant Extractsturmeric extractankylosing spondylitisCurcuma longa extractcurcuminjuvenile idiopathic arthritismeta-analysisosteoarthritisrheumatoid arthritissystematic review

Identifiers

PMID35935936
PMCPMC9353077
OpenAlexW4286447666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.