Evidence map›Paper›PMID 35935990›Full record

ArticleFrontiers in immunology2022

Fine-tuning of microglia polarization prevents diabetes-associated cerebral atherosclerosis.

Xuan Zhu, Pengfei Xing, Ping Zhang, Minmin Zhang, Hongjian Shen, Lei Chen, Fang Shen, Yi Jiang, Hui Yuan, Lei Zhang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Xuan ZhuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Pengfei XingDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Ping ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Minmin ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Hongjian ShenDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Lei ChenDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Fang ShenDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yi JiangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Hui YuanDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Lei ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Jing WangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Xiongfeng WuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yu ZhouDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Tao WuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Benqiang DengDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Jianmin LiuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yongwei ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Pengfei YangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Changhai Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes increases the occurrence and severity of atherosclerosis. When plaques form in brain vessels, cerebral atherosclerosis causes thickness, rigidity, and unstableness of cerebral artery walls, leading to severe complications like stroke and contributing to cognitive impairment. So far, the molecular mechanism underlying cerebral atherosclerosis is not determined. Moreover, effective intervention strategies are lacking. In this study, we showed that polarization of microglia, the resident macrophage in the central nervous system, appeared to play a critical role in the pathological progression of cerebral atherosclerosis. Microglia likely underwent an M2c-like polarization in an environment long exposed to high glucose. Experimental suppression of microglia M2c polarization was achieved through transduction of microglia with an adeno-associated virus (serotype AAV-PHP.B) carrying siRNA for interleukin-10 (IL-10) under the control of a microglia-specific TMEM119 promoter, which significantly attenuated diabetes-associated cerebral atherosclerosis in a mouse model. Thus, our study suggests a novel translational strategy to prevent diabetes-associated cerebral atherosclerosis through

Indexed as

Diabetes MellitusIntracranial ArteriosclerosisStrokeAnimalsInfarction, Middle Cerebral ArteryMiceMicrogliacerebral atherosclerosisinterleukin-10 (IL-10)microgliapolarizationTMEM119

Identifiers

PMID35935990
PMCPMC9353938
OpenAlexW4286698066

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.