Evidence map›Paper›PMID 35937499›Full record

ArticleOncotarget2022

A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling.

Stephan J Matissek, Mona Karbalivand, Weiguo Han, Ava Boutilier, Estefania Yzar-Garcia, Laura L Kehoe, Devin Storm Gardner, Adam Hage, Krista Fleck, Vicki Jeffers and 2 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Stephan J MatissekDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Mona KarbalivandDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Weiguo HanDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Ava BoutilierDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Estefania Yzar-GarciaDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Laura L KehoeDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Devin Storm GardnerDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Adam HageDeparment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Krista FleckDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Vicki JeffersDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Ricardo RajsbaumDeparment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Sherine F ElsawaDeparment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
University of New Hampshire · USThe University of Texas Medical Branch at Galveston · US

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8M
Regulation of Ebola virus replication by the host ubiquitin systemR01AI134907 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GIRALDO, MARIA ISABEL · 2018 to 2022
$3.1M
The Role of the Host Ubiquitin System in Promoting SARS-CoV-2 Replication and PathogenesisR01AI166668 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAJSBAUM, RICARDO · 2021 to 2025
$2.6M
The Role of TRIM6 and Ubiquitin in Influenza Virus-Induced PathologyR01AI155466 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Ricardo Rajsbaum · 2021 to 2026
$2.5M
NIAID NIH HHS R01 AI134907NIAID NIH HHS R01 AI155466NIAID NIH HHS R01 AI166668NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

The transcription factor GLI3 is a member of the GLI family and has been shown to be regulated by canonical hedgehog (HH) signaling through smoothened (SMO). Little is known about SMO-independent regulation of GLI3. Here, we identify TLR signaling as a novel pathway regulating GLI3 expression. We show that GLI3 expression is induced by LPS/TLR4 in human monocyte cell lines and peripheral blood CD14

Indexed as

LipopolysaccharidesToll-Like Receptor 4Adaptor Proteins, Vesicular TransportAnimalsCytokinesHedgehog ProteinsHumansInterferon Regulatory Factor-3LigandsMiceMyeloid Differentiation Factor 88Nerve Tissue ProteinsNF-kappa BPoly I-CToll-Like Receptor 3Toll-Like ReceptorsAdaptor Proteins, Vesicular TransportCytokinesGLI3 protein, humanGli3 protein, mouseHedgehog ProteinsInterferon Regulatory Factor-3LigandsLipopolysaccharidesMyeloid Differentiation Factor 88Nerve Tissue ProteinsNF-kappa BPoly I-CToll-Like Receptor 3Toll-Like Receptor 4Toll-Like ReceptorsTumor Necrosis Factor-alphaZinc Finger Protein Gli3GLI3inflammationTLR

Identifiers

PMID35937499
PMCPMC9348707
OpenAlexW4289593839

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.