Evidence map›Paper›PMID 35944007›Full record

ReviewPhysiology (Bethesda, Md.)2022

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease.

Timothy D O'Connell, Katherine A Murphy, Naixin Zhang, Sara J Puccini, Chastity L Healy, Brian A Harsch, Michael J Zhang, Gregory C Shearer

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiology (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. FFAR4 Deficiency Increases Necrotic Cores in Advanced Lesions of ApoEArteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Timothy D O'ConnellDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-0560-3428
Katherine A MurphyDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Naixin ZhangDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Sara J PucciniDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Chastity L HealyDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Brian A HarschDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania.
Michael J ZhangDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Gregory C ShearerDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania.
University of Minnesota · USPennsylvania State University · US

Funding

Minnesota Obesity Prevention Training (MnOPT)T32DK083250 · NIDDK · UNIVERSITY OF MINNESOTA · PI KOTZ, CATHERINE M, LASKA, MELISSA N. · 2010 to 2024
$5.1M
Free fatty acid receptor 4 cardioprotective effects in cardiac ischemic injuryR01HL152215 · NHLBI · UNIVERSITY OF MINNESOTA · PI O'CONNELL, TIMOTHY D, SHEARER, GREGORY C · 2020 to 2024
$3.4M
Eicosapentaenoic acid activation of free fatty acid receptor 4 prevents fibrosis, microvascular rarefaction, and diastolic dysfunction; implications for heart failure preserved ejection fractionR01HL130099 · NHLBI · UNIVERSITY OF MINNESOTA · PI O'CONNELL, TIMOTHY D, SHEARER, GREGORY C · 2016 to 2019
$1.5M
Mechanisms of free fatty acid receptor 4 signaling in the ischemic myocardiumF32HL152523 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, MICHAEL JINGYUAN · 2020 to 2021
$143k
NHLBI NIH HHS F32 HL152523NHLBI NIH HHS R01 HL130099NHLBI NIH HHS R01 HL152215NIDDK NIH HHS T32 DK083250
6 · The paper itself

Abstract

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

Indexed as

Cardiovascular DiseasesFatty Acids, Omega-3Fatty Acids, NonesterifiedHumansInflammationSignal TransductionFatty Acids, NonesterifiedFatty Acids, Omega-318-hydroxyeicosapentaenoic acid (18-HEPE)cardiometabolic diseasefree fatty acid receptor 4 (Ffar4)heartspecialized proresolving mediators (SPM)ω3-polyunsaturated fatty acids (ω3-PUFAs)

Identifiers

PMID35944007
PMCPMC9550565
OpenAlexW4290779340

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.