Evidence map›Paper›PMID 35946572›Full record

ArticleThe Journal of physiology2023

Changes in cellular Ca

Kenneth T MacLeod

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Digoxin and its NaBioorganic & medicinal chemistry · 2024
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kenneth T MacLeodNational Heart & Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital, London, UK.ORCID 0000-0003-0633-1591
Hammersmith Hospital · GB

Funding

British Heart Foundation N/ABritish Heart Foundation SP/16/2/32004
6 · The paper itself

Abstract

In adapting to disease and loss of tissue, the heart shows great phenotypic plasticity that involves changes to its structure, composition and electrophysiology. Together with parallel whole body cardiovascular adaptations, the initial decline in cardiac function resulting from the insult is compensated. However, in the long term, the heart muscle begins to fail and patients with this condition have a very poor prognosis, with many dying from disturbances of rhythm. The surviving myocytes of these hearts gain Na

Indexed as

Heart FailureCalciumDiastoleHeartHumansMyocardial ContractionMyocardiumMyocytes, CardiacSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium ExchangerCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium Exchangercalcium influxheart failureNa+/Ca2+ exchangeNa+/K+ pumpsodium homeostasis

Identifiers

PMID35946572
PMCPMC10952717
OpenAlexW4292679732

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.