ArticleNPJ microgravity2022
Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission.
Article in NPJ microgravity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Automated behavioral segmentation and markerless pose tracking of mice during spaceflight.bioRxiv : the preprint server for biology · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- [Potential biological mechanisms underlying spaceflight-induced depression symptoms in astronauts].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Resistance and Aerobic Preconditioning Delays Unloading-Induced Multisystemic Physiological Changes: The NEBULA Project.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Article
- Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system.Scientific reports · 2025Article
- Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy.Research (Washington, D.C.) · 2025Article
- Transcriptomic comparison of corneal endothelial cells in young versus old corneas.Scientific reports · 2024Article
- IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance.iScience · 2024Article
- Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response.Nature communications · 2024Article
- Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice.Nature communications · 2024Article
- NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions.NPJ microgravity · 2024Review
- "Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight".Frontiers in immunology · 2024Review
- Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health.Frontiers in cellular neuroscience · 2024Review
- Long-Term Simulation of Microgravity Induces Changes in Gene Expression in Breast Cancer Cells.International journal of molecular sciences · 2023Article
- Nourishing the brain on deep space missions: nutritional psychiatry in promoting resilience.Frontiers in neural circuits · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that neuroinflammatory response plays an important role in the neurovascular remodeling in the brain after stress. The goal of the present study was to characterize changes in the gene expression profiles associated with neuroinflammation, neuronal function, metabolism and stress in mouse brain tissue. Ten-week old male C57BL/6 mice were launched to the International Space Station (ISS) on SpaceX-12 for a 35-day mission. Within 38 ± 4 h of splashdown, mice were returned to Earth alive. Brain tissues were collected for analysis. A novel digital color-coded barcode counting technology (NanoString
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.