Evidence map›Paper›PMID 35950503›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis.

Piu Saha, Blair Mell, Rachel M Golonka, Venugopal R Bovilla, Ahmed A Abokor, Xue Mei, Beng San Yeoh, Peter A Doris, Andrew T Gewirtz, Bina Joe and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Piu SahaUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Blair MellUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Rachel M GolonkaUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Venugopal R BovillaUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Ahmed A AbokorUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Xue MeiUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Beng San YeohUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).
Peter A DorisBrown Foundation Institute of Molecular Medicine, University of Texas McGovern Medical School, Houston' TX (P.A.D.).ORCID 0000-0002-0565-7939
Andrew T GewirtzCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta' GA (A.T.G.).
Bina JoeUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).ORCID 0000-0002-2385-7061
Matam Vijay-KumarUT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (P.S., B.M., R.M.G., V.R.B., A.A.A., X.M., B.S.Y., B.J., M.V.-K.).ORCID 0000-0002-8732-0167
University of Toledo · USBrown Foundation · USGeorgia State University · US

Funding

Genetic, Epigenetic and Dietary Salt effects on Microbiota and HypertensionR01HL143082 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI JOE, BINA · 2018 to 2021
$2.6M
Long-read assembly and annotation of rat genomes that are important models of complex genetic diseaseR01HG011252 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A, KALBFLEISCH, THEODORE · 2021 to 2025
$2.0M
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular CarcinomaR01CA219144 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI VIJAY-KUMAR, MATAM · 2017 to 2021
$1.6M
Immunogenetics of common polygenic renal diseaseR01DK114235 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A · 2017 to 2020
$1.4M
NCI NIH HHS R01 CA219144NHGRI NIH HHS R01 HG011252NHLBI NIH HHS R01 HL143082NIDDK NIH HHS R01 DK114235
6 · The paper itself

Abstract

backgroundThe spontaneously hypertensive rat (SHR) is extensively used to study hypertension. Gut microbiota dysbiosis is a notable feature in SHR for reasons unknown. Immunoglobulin A (IgA) is a major host factor required for gut microbiota homeostasis. We hypothesized that inadequate IgA contributes to gut microbiota dysbiosis in SHR.

methodsIgA was measured in feces, cecum, serum, liver, gut-associated lymphoid tissue, and milk from SHR and Wistar Kyoto rats. IgA regulatory factors like IgM, IgG, and

resultsCompared with Wistar Kyoto rats, SHR displayed remarkably near-deficient IgA levels accompanied by compensatory increases in serum IgM and IgG and gut-liver

conclusionsThis study is the first to reveal IgA deficiency in SHR as one host factor associated with gut microbiota dysbiosis and invigorates future research to determine the pathophysiological role of IgA in hypertension.

Indexed as

HypertensionIgA DeficiencyAnimalsBlood PressureDysbiosisImmunoglobulin AImmunoglobulin GImmunoglobulin MRatsRats, Inbred SHRRats, Inbred WKYImmunoglobulin AImmunoglobulin GImmunoglobulin MB cellsblood pressureflagellingut microbiotamilkpolymeric immunoglobulin receptors

Identifiers

PMID35950503
PMCPMC9458624
OpenAlexW4291019371

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.