Evidence map›Paper›PMID 35954173›Full record

ArticleCells2022

Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients.

Anindita Ravindran, Kimiko L Krieger, Akash K Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu and 14 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 2 countries.

Anindita RavindranDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Kimiko L KriegerDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.ORCID 0000-0002-7432-2729
Akash K KaushikDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Hélène HovingtonFaculty of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval Research Center (CRCHUQc-UL) and Université Laval, Québec, QC G1V 4G2, Canada.ORCID 0000-0002-5500-5648
Sadia MehdiFaculty of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval Research Center (CRCHUQc-UL) and Université Laval, Québec, QC G1V 4G2, Canada.
Danthasinghe Waduge Badrajee PiyarathnaDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Vasanta PutluriAdvanced Technology Core, Baylor College of Medicine, Houston, TX 77030, USA.
Paul BasilDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Uttam RasailyDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Franklin GuDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Truong DangDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Jong Min ChoiVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-5282-7697
Rajni SonavaneDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Sung Yun JungVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-1521-7977
Lisha WangMichigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.
Rohit MehraMichigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.
Nancy L WeigelDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Nagireddy PutluriDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
David R RowleyDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Ganesh S PalapattuRogel Cancer Center, Michigan Medicine, Ann Arbor, MI 48109, USA.
Chantal GuillemetteFaculty of Pharmacy, Pharmacogenomics Laboratory, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval Research Center (CRCHUQc-UL) and Université Laval, Québec, QC G1V 4G2, Canada.
Louis LacombeFaculty of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval Research Center (CRCHUQc-UL) and Université Laval, Québec, QC G1V 4G2, Canada.
Éric LévesqueFaculty of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval Research Center (CRCHUQc-UL) and Université Laval, Québec, QC G1V 4G2, Canada.
Arun SreekumarDepartment of Molecular and Cell Biology, Baylor College of Medicine, 120D, Jewish Building, Houston, TX 77030, USA.
Baylor College of Medicine · USCentre hospitalier universitaire de Québec · CAUniversity of Michigan · USMichigan Center for Translational Pathology · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7M
Elevated homocysteine in African American Prostate Cancer: Association with Diet and Dietary practices, evaluating its biomarker potential, and characterizing its tumor promoting functionR01CA267090 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Luis Rustveld, Arun Sreekumar · 2022 to 2026
$2.3M
Metabolic Rewiring Promotes AA PCa by Regulating Stromal-Epithelial InteractionR01CA227559 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PALAPATTU, GANESH S, SREEKUMAR, ARUN · 2019 to 2023
$2.1M
CIHR FRN-408093NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA227559NCI NIH HHS R01 CA267090NIDDK NIH HHS P30 DK056338NIEHS NIH HHS P30 ES030285
6 · The paper itself

Abstract

Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial, the precise reasons for this are unknown. Here, we identified a higher expression of the metabolic enzyme UGT2B28 in localized PCa and metastatic disease compared to benign adjacent tissue, in AA PCa compared to benign adjacent tissue, and in AA PCa compared to European American (EA) PCa.

Indexed as

AndrogensProstatic NeoplasmsBlack or African AmericanGlucuronosyltransferaseHumansMaleNeoplastic ProcessesUridine DiphosphateAndrogensGlucuronosyltransferaseUDP-glucuronosyltransferase, UGT2B28Uridine DiphosphateAfrican American prostate cancerandrogen signalingglucuronidationmetabolic regulationprostate cancertumorigenesisUGT2B28

Identifiers

PMID35954173
PMCPMC9367340
OpenAlexW4289110538

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.