Evidence map›Paper›PMID 35954178›Full record

ArticleCells2022

Smooth Muscle Myosin Localizes at the Leading Edge and Regulates the Redistribution of Actin-regulatory Proteins during Migration.

Ruping Wang, Eylon Arbel, Dale D Tang

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Characterization of Corneal Defects in ATG7-Deficient Mice.International journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ruping WangDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, NY 12208, USA.
Eylon ArbelDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, NY 12208, USA.
Dale D TangDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, NY 12208, USA.ORCID 0000-0002-7339-9249
Albany Medical Center Hospital · US

Funding

Reorganization of the Actin Cytoskeleton in Airway Smooth MuscleR01HL110951 · NHLBI · ALBANY MEDICAL COLLEGE · PI TANG, DALE D. · 2012 to 2022
$3.6M
PLK1 Regulation of Airway Smooth MuscleR01HL130304 · NHLBI · ALBANY MEDICAL COLLEGE · PI TANG, DALE D. · 2016 to 2024
$3.5M
Cooperative targeting of pharmacomechanical coupling and the actin cytoskeleton to regulate ASM contractionR01HL145392 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI KRISHNAN, RAMASWAMY, PENN, RAYMOND B. · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL110951NHLBI NIH HHS R01 HL130304NHLBI NIH HHS R01 HL145392
6 · The paper itself

Abstract

Airway smooth muscle cell migration plays an essential role in airway development, repair, and remodeling. Smooth muscle myosin II has been traditionally thought to localize in the cytoplasm solely and regulates cell migration by affecting stress fiber formation and focal adhesion assembly. In this study, we unexpectedly found that 20-kDa myosin light chain (MLC

Indexed as

ActinsSmooth Muscle MyosinsIntegrin beta1Muscle, SmoothMyosin Light ChainsActinsIntegrin beta1Myosin Light ChainsSmooth Muscle Myosinsactin-associated proteinsleading edgemigrationmyosinsmooth muscle

Identifiers

PMID35954178
PMCPMC9367404
OpenAlexW4289111241

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.