ReviewInternational journal of molecular sciences2022
Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Lineages and sublineages of high-risk human papillomavirus types associated with cervical cancer and precancer: a systematic review and meta-analysis.Journal of the National Cancer Institute · 2025Pooled it
- HPV-16 lineages among women in Africa: a systematic review with meta-analysis.Systematic reviews · 2025Pooled it
- Molecular epidemiology of human papillomavirus variants in cervical cancer in India.The Indian journal of medical research · 2024Pooled it
- [Risk factors for cervical intraepithelial lesions among beneficiaries of second-level care].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- RBM15 in diseases: Molecular mechanisms and clinical opportunities from RNA mGenes & diseases · 2026Review
- Comparative Anticancer Activity of Extract, Partitions, and a Two-Acetogenin Mixture from Mexican Creole Avocado Seed.Molecules (Basel, Switzerland) · 2026Article
- Sequential HPV16 variant infections in the genital epithelium and anal canal of men.International journal of cancer · 2026Article
- Clinical significance ofFrontiers in cellular and infection microbiology · 2026Article
- Drug Repositioning for HPV Clade-Specific Cervicouterine Cancer Using the OCTAD Pipeline.International journal of molecular sciences · 2025Article
- Spatial Epidemiology of Human Papillomavirus Screening Coverage in Mexico, 2013-2019.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The HGF/Met Receptor Mediates Cytotoxic Effect of Bacterial Cyclodipeptides in Human Cervical Cancer Cells.Current cancer drug targets · 2025Article
- Histopathological Correlation of Cases with Epithelial Cell Abnormality Detected in Cervicovaginal Smear Screenings of Turkish Women and Their Association with HPV Subtypes.International journal of general medicine · 2025Article
- Barriers and facilitators for adherence to follow-up by HR-HPV-positive women with premalignant cervical lesions: a mixed-design study in Mexico.BMC women's health · 2024Article
- Human papillomavirus molecular prevalence in south China and the impact on vaginal microbiome of unvaccinated women.mSystems · 2024Article
- HPV Infections-Classification, Pathogenesis, and Potential New Therapies.International journal of molecular sciences · 2024Review
- Genetic variability of human papillomavirus type 18 based on E6, E7 and L1 genes in central China.Virology journal · 2024Article
- Article
- Article
- Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China.Virology journal · 2023Article
- Transcriptional activity of the long control region in human papillomavirus type 33 intratype variants.Virology journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cervical cancer (CC) continues to be a major public health problem in Mexico, ranking second among cancers in women. A persistent infection with human papillomaviruses (HPV) is the main risk factor for CC development. In addition, a significant fraction of other cancers including those of the anus, oropharynx, and penis are also related to HPV infection. In CC, HPV-16 is the most prevalent high-risk HPV type, followed by HPV-18, both being responsible for 70% of cases. HPV intratype variant lineages differ in nucleotide sequences by 1-10%, while sublineages differ by 0.5-1%. Several studies have postulated that the nucleotide changes that occur between HPV intratype variants are reflected in functional differences and in pathogenicity. Moreover, it has been demonstrated that HPV-16 and -18 intratype variants differentially affect molecular processes in infected cells, changing their biological behavior that finally impacts in the clinical outcome of patients. Mexico has participated in providing knowledge on the geographical distribution of intratype variants of the most prevalent HPVs in premalignant lesions of the cervix and cervical cancer, as well as in other HPV-related tumors. In addition, functional studies have been carried out to assess the cellular effects of intratype variations in HPV proteins. This review addresses the state of the art on the epidemiology of HPV-16 and HPV-18 intratype variants in the Mexican population, as well as their association with persistence, precancer and cervical cancer, and functional aspects related to their biological behavior.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.